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Selective CDK7 Inhibition Suppresses Cell Cycle Progression and MYC Signaling While Enhancing Apoptosis in Therapy-resistant Estrogen Receptor-positive Breast Cancer.
Guarducci C, Nardone A, Russo D, Nagy Z, Heraud C, Grinshpun A, Zhang Q, Freelander A, Leventhal MJ, Feit A, Cohen Feit G, Feiglin A, Liu W, Hermida-Prado F, Kesten N, Ma W, De Angelis C, Morlando A, O'Donnell M, Naumenko S, Huang S, Nguyen QD, Huang Y, Malorni L, Bergholz JS, Zhao JJ, Fraenkel E, Lim E, Schiff R, Shapiro GI, Jeselsohn R. Guarducci C, et al. Among authors: fraenkel e. Clin Cancer Res. 2024 May 1;30(9):1889-1905. doi: 10.1158/1078-0432.CCR-23-2975. Clin Cancer Res. 2024. PMID: 38381406 Free PMC article.
DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets.
Hanaford AR, Archer TC, Price A, Kahlert UD, Maciaczyk J, Nikkhah G, Kim JW, Ehrenberger T, Clemons PA, Dančík V, Seashore-Ludlow B, Viswanathan V, Stewart ML, Rees MG, Shamji A, Schreiber S, Fraenkel E, Pomeroy SL, Mesirov JP, Tamayo P, Eberhart CG, Raabe EH. Hanaford AR, et al. Among authors: fraenkel e. Clin Cancer Res. 2016 Aug 1;22(15):3903-14. doi: 10.1158/1078-0432.CCR-15-3011. Epub 2016 Mar 24. Clin Cancer Res. 2016. PMID: 27012813 Free PMC article.
Genome-scale screens identify factors regulating tumor cell responses to natural killer cells.
Sheffer M, Lowry E, Beelen N, Borah M, Amara SN, Mader CC, Roth JA, Tsherniak A, Freeman SS, Dashevsky O, Gandolfi S, Bender S, Bryan JG, Zhu C, Wang L, Tariq I, Kamath GM, Simoes RM, Dhimolea E, Yu C, Hu Y, Dufva O, Giannakis M, Syrgkanis V, Fraenkel E, Golub T, Romee R, Mustjoki S, Culhane AC, Wieten L, Mitsiades CS. Sheffer M, et al. Among authors: fraenkel e. Nat Genet. 2021 Aug;53(8):1196-1206. doi: 10.1038/s41588-021-00889-w. Epub 2021 Jul 12. Nat Genet. 2021. PMID: 34253920
Integrated network analyses for functional genomic studies in cancer.
Wilson JL, Hemann MT, Fraenkel E, Lauffenburger DA. Wilson JL, et al. Among authors: fraenkel e. Semin Cancer Biol. 2013 Aug;23(4):213-8. doi: 10.1016/j.semcancer.2013.06.004. Epub 2013 Jun 27. Semin Cancer Biol. 2013. PMID: 23811269 Free PMC article. Review.
SAMNetWeb: identifying condition-specific networks linking signaling and transcription.
Gosline SJ, Oh C, Fraenkel E. Gosline SJ, et al. Among authors: fraenkel e. Bioinformatics. 2015 Apr 1;31(7):1124-6. doi: 10.1093/bioinformatics/btu748. Epub 2014 Nov 19. Bioinformatics. 2015. PMID: 25414365 Free PMC article.
These tools are primarily designed to analyse data from a single experiment (e.g. drug treatment versus control), creating a need for computational algorithms that can handle heterogeneous datasets across multiple experimental conditions at once. ...AVAILABILITY AND IMPLEM …
These tools are primarily designed to analyse data from a single experiment (e.g. drug treatment versus control), creating a need for …
Intratumoral drug-releasing microdevices allow in situ high-throughput pharmaco phenotyping in patients with gliomas.
Peruzzi P, Dominas C, Fell G, Bernstock JD, Blitz S, Mazzetti D, Zdioruk M, Dawood HY, Triggs DV, Ahn SW, Bhagavatula SK, Davidson SM, Tatarova Z, Pannell M, Truman K, Ball A, Gold MP, Pister V, Fraenkel E, Chiocca EA, Ligon KL, Wen PY, Jonas O. Peruzzi P, et al. Among authors: fraenkel e. Sci Transl Med. 2023 Sep 6;15(712):eadi0069. doi: 10.1126/scitranslmed.adi0069. Epub 2023 Sep 6. Sci Transl Med. 2023. PMID: 37672566 Free PMC article.
Dictionary of immune responses to cytokines at single-cell resolution.
Cui A, Huang T, Li S, Ma A, Pérez JL, Sander C, Keskin DB, Wu CJ, Fraenkel E, Hacohen N. Cui A, et al. Among authors: fraenkel e. Nature. 2024 Jan;625(7994):377-384. doi: 10.1038/s41586-023-06816-9. Epub 2023 Dec 6. Nature. 2024. PMID: 38057668 Free PMC article.
149 results