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Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy.
Hoogenboezem EN, Patel SS, Lo JH, Cavnar AB, Babb LM, Francini N, Gbur EF, Patil P, Colazo JM, Michell DL, Sanchez VM, McCune JT, Ma J, DeJulius CR, Lee LH, Rosch JC, Allen RM, Stokes LD, Hill JL, Vickers KC, Cook RS, Duvall CL. Hoogenboezem EN, et al. Among authors: cavnar ab. Nat Commun. 2024 Feb 21;15(1):1581. doi: 10.1038/s41467-024-45609-0. Nat Commun. 2024. PMID: 38383524 Free PMC article.
Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy.
Hoogenboezem EN, Patel SS, Cavnar AB, Lo JH, Babb LM, Francini N, Patil P, Colazo JM, Michell DL, Sanchez VM, McCune JT, Ma J, DeJulius CR, Lee LH, Rosch JC, Allen RM, Stokes LD, Hill JL, Vickers KC, Cook RS, Duvall CL. Hoogenboezem EN, et al. Among authors: cavnar ab. bioRxiv [Preprint]. 2023 Feb 15:2023.02.14.528574. doi: 10.1101/2023.02.14.528574. bioRxiv. 2023. PMID: 36824780 Free PMC article. Updated. Preprint.
LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8.
Allen RM, Michell DL, Cavnar AB, Zhu W, Makhijani N, Contreras DM, Raby CA, Semler EM, DeJulius C, Castleberry M, Zhang Y, Ramirez-Solano M, Zhao S, Duvall C, Doran AC, Sheng Q, Linton MF, Vickers KC. Allen RM, et al. Among authors: cavnar ab. Nat Cell Biol. 2022 Dec;24(12):1701-1713. doi: 10.1038/s41556-022-01030-7. Epub 2022 Dec 6. Nat Cell Biol. 2022. PMID: 36474072 Free PMC article.
Elucidation of physico-chemical principles of high-density lipoprotein-small RNA binding interactions.
Michell DL, Allen RM, Cavnar AB, Contreras DM, Yu M, Semler EM, Massick C, Raby CA, Castleberry M, Ramirez MA, Zhu W, May-Zhang L, Ifrim A, Carr JJ, Terry JG, Schwendeman A, Davies SS, Sheng Q, Linton MF, Vickers KC. Michell DL, et al. Among authors: cavnar ab. J Biol Chem. 2022 Jun;298(6):101952. doi: 10.1016/j.jbc.2022.101952. Epub 2022 Apr 18. J Biol Chem. 2022. PMID: 35447119 Free PMC article.
Kidney injury-mediated disruption of intestinal lymphatics involves dicarbonyl-modified lipoproteins.
Zhong J, Yang HC, Yermalitsky V, Shelton EL, Otsuka T, Wiese CB, May-Zhang LS, Banan B, Abumrad N, Huang J, Cavnar AB, Kirabo A, Yancey PG, Fogo AB, Vickers KC, Linton MF, Davies SS, Kon V. Zhong J, et al. Among authors: cavnar ab. Kidney Int. 2021 Sep;100(3):585-596. doi: 10.1016/j.kint.2021.05.028. Epub 2021 Jun 5. Kidney Int. 2021. PMID: 34102217 Free PMC article.