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Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy.
Hoogenboezem EN, Patel SS, Lo JH, Cavnar AB, Babb LM, Francini N, Gbur EF, Patil P, Colazo JM, Michell DL, Sanchez VM, McCune JT, Ma J, DeJulius CR, Lee LH, Rosch JC, Allen RM, Stokes LD, Hill JL, Vickers KC, Cook RS, Duvall CL. Hoogenboezem EN, et al. Nat Commun. 2024 Feb 21;15(1):1581. doi: 10.1038/s41467-024-45609-0. Nat Commun. 2024. PMID: 38383524 Free PMC article.
Albumin-binding RNAi Conjugate for Carrier Free Treatment of Arthritis.
Colazo JM, Hoogenboezem EN, Keech MC, Francini N, Shah V, Yu F, Lo JH, Sorets AG, McCune JT, Cho H, DeJulius CR, Michell DL, Maerz T, Vickers KC, Gibson-Corley KN, Hasty KA, Crofford L, Cook RS, Duvall CL. Colazo JM, et al. Among authors: hoogenboezem en. bioRxiv [Preprint]. 2023 Dec 28:2023.05.31.542971. doi: 10.1101/2023.05.31.542971. bioRxiv. 2023. PMID: 37333210 Free PMC article. Preprint.
Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing.
Patel SS, Hoogenboezem EN, Yu F, DeJulius CR, Fletcher RB, Sorets AG, Cherry FK, Lo JH, Bezold MG, Francini N, d'Arcy R, Brasuell JE, Cook RS, Duvall CL. Patel SS, et al. Among authors: hoogenboezem en. Biomaterials. 2023 Jun;297:122098. doi: 10.1016/j.biomaterials.2023.122098. Epub 2023 Mar 28. Biomaterials. 2023. PMID: 37031547
Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy.
Hoogenboezem EN, Patel SS, Cavnar AB, Lo JH, Babb LM, Francini N, Patil P, Colazo JM, Michell DL, Sanchez VM, McCune JT, Ma J, DeJulius CR, Lee LH, Rosch JC, Allen RM, Stokes LD, Hill JL, Vickers KC, Cook RS, Duvall CL. Hoogenboezem EN, et al. bioRxiv [Preprint]. 2023 Feb 15:2023.02.14.528574. doi: 10.1101/2023.02.14.528574. bioRxiv. 2023. PMID: 36824780 Free PMC article. Updated. Preprint.
Albumin-Binding Aptamer Chimeras for Improved siRNA Bioavailability.
Rosch JC, Hoogenboezem EN, Sorets AG, Duvall CL, Lippmann ES. Rosch JC, et al. Among authors: hoogenboezem en. Cell Mol Bioeng. 2022 Jan 24;15(2):161-173. doi: 10.1007/s12195-022-00718-y. eCollection 2022 Apr. Cell Mol Bioeng. 2022. PMID: 35401842 Free PMC article.
Kupffer cell release of platelet activating factor drives dose limiting toxicities of nucleic acid nanocarriers.
Jackson MA, Patel SS, Yu F, Cottam MA, Glass EB, Hoogenboezem EN, Fletcher RB, Dollinger BR, Patil P, Liu DD, Kelly IB, Bedingfield SK, King AR, Miles RE, Hasty AM, Giorgio TD, Duvall CL. Jackson MA, et al. Among authors: hoogenboezem en. Biomaterials. 2021 Jan;268:120528. doi: 10.1016/j.biomaterials.2020.120528. Epub 2020 Nov 23. Biomaterials. 2021. PMID: 33285438 Free PMC article.
Dual carrier-cargo hydrophobization and charge ratio optimization improve the systemic circulation and safety of zwitterionic nano-polyplexes.
Jackson MA, Bedingfield SK, Yu F, Stokan ME, Miles RE, Curvino EJ, Hoogenboezem EN, Bonami RH, Patel SS, Kendall PL, Giorgio TD, Duvall CL. Jackson MA, et al. Among authors: hoogenboezem en. Biomaterials. 2019 Feb;192:245-259. doi: 10.1016/j.biomaterials.2018.11.010. Epub 2018 Nov 10. Biomaterials. 2019. PMID: 30458360 Free PMC article.
Harnessing albumin as a carrier for cancer therapies.
Hoogenboezem EN, Duvall CL. Hoogenboezem EN, et al. Adv Drug Deliv Rev. 2018 May;130:73-89. doi: 10.1016/j.addr.2018.07.011. Epub 2018 Jul 27. Adv Drug Deliv Rev. 2018. PMID: 30012492 Free PMC article. Review.