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Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy.
Hoogenboezem EN, Patel SS, Lo JH, Cavnar AB, Babb LM, Francini N, Gbur EF, Patil P, Colazo JM, Michell DL, Sanchez VM, McCune JT, Ma J, DeJulius CR, Lee LH, Rosch JC, Allen RM, Stokes LD, Hill JL, Vickers KC, Cook RS, Duvall CL. Hoogenboezem EN, et al. Among authors: patel ss. Nat Commun. 2024 Feb 21;15(1):1581. doi: 10.1038/s41467-024-45609-0. Nat Commun. 2024. PMID: 38383524 Free PMC article.
Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy.
Hoogenboezem EN, Patel SS, Cavnar AB, Lo JH, Babb LM, Francini N, Patil P, Colazo JM, Michell DL, Sanchez VM, McCune JT, Ma J, DeJulius CR, Lee LH, Rosch JC, Allen RM, Stokes LD, Hill JL, Vickers KC, Cook RS, Duvall CL. Hoogenboezem EN, et al. Among authors: patel ss. bioRxiv [Preprint]. 2023 Feb 15:2023.02.14.528574. doi: 10.1101/2023.02.14.528574. bioRxiv. 2023. PMID: 36824780 Free PMC article. Updated. Preprint.
Dual carrier-cargo hydrophobization and charge ratio optimization improve the systemic circulation and safety of zwitterionic nano-polyplexes.
Jackson MA, Bedingfield SK, Yu F, Stokan ME, Miles RE, Curvino EJ, Hoogenboezem EN, Bonami RH, Patel SS, Kendall PL, Giorgio TD, Duvall CL. Jackson MA, et al. Among authors: patel ss. Biomaterials. 2019 Feb;192:245-259. doi: 10.1016/j.biomaterials.2018.11.010. Epub 2018 Nov 10. Biomaterials. 2019. PMID: 30458360 Free PMC article.
Kupffer cell release of platelet activating factor drives dose limiting toxicities of nucleic acid nanocarriers.
Jackson MA, Patel SS, Yu F, Cottam MA, Glass EB, Hoogenboezem EN, Fletcher RB, Dollinger BR, Patil P, Liu DD, Kelly IB, Bedingfield SK, King AR, Miles RE, Hasty AM, Giorgio TD, Duvall CL. Jackson MA, et al. Among authors: patel ss. Biomaterials. 2021 Jan;268:120528. doi: 10.1016/j.biomaterials.2020.120528. Epub 2020 Nov 23. Biomaterials. 2021. PMID: 33285438 Free PMC article.
Nonviral In Vivo Delivery of CRISPR-Cas9 Using Protein-Agnostic, High-Loading Porous Silicon and Polymer Nanoparticles.
Fletcher RB, Stokes LD, Kelly IB 3rd, Henderson KM, Vallecillo-Viejo IC, Colazo JM, Wong BV, Yu F, d'Arcy R, Struthers MN, Evans BC, Ayers J, Castanon M, Weirich MJ, Reilly SK, Patel SS, Ivanova YI, Silvera Batista CA, Weiss SM, Gersbach CA, Brunger JM, Duvall CL. Fletcher RB, et al. Among authors: patel ss. ACS Nano. 2023 Sep 12;17(17):16412-16431. doi: 10.1021/acsnano.2c12261. Epub 2023 Aug 15. ACS Nano. 2023. PMID: 37582231
Identification and outcomes of KDIGO-defined chronic kidney disease in 1.4 million U.S. Veterans with heart failure.
Patel SS, Raman VK, Zhang S, Deedwania P, Zeng-Treitler Q, Wu WC, Lam PH, Bakris G, Moore H, Heidenreich PA, Rangaswami J, Morgan CJ, Cheng Y, Sheriff HM, Faselis C, Mehta RL, Anker SD, Fonarow GC, Ahmed A. Patel SS, et al. Eur J Heart Fail. 2024 May 3. doi: 10.1002/ejhf.3210. Online ahead of print. Eur J Heart Fail. 2024. PMID: 38700246
795 results