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Targeted protein degradation via intramolecular bivalent glues.
Hsia O, Hinterndorfer M, Cowan AD, Iso K, Ishida T, Sundaramoorthy R, Nakasone MA, Imrichova H, Schätz C, Rukavina A, Husnjak K, Wegner M, Correa-Sáez A, Craigon C, Casement R, Maniaci C, Testa A, Kaulich M, Dikic I, Winter GE, Ciulli A. Hsia O, et al. Among authors: nakasone ma. Nature. 2024 Mar;627(8002):204-211. doi: 10.1038/s41586-024-07089-6. Epub 2024 Feb 21. Nature. 2024. PMID: 38383787 Free PMC article.
Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer.
Villar VH, Allega MF, Deshmukh R, Ackermann T, Nakasone MA, Vande Voorde J, Drake TM, Oetjen J, Bloom A, Nixon C, Müller M, May S, Tan EH, Vereecke L, Jans M, Blancke G, Murphy DJ, Huang DT, Lewis DY, Bird TG, Sansom OJ, Blyth K, Sumpton D, Tardito S. Villar VH, et al. Among authors: nakasone ma. Nat Chem Biol. 2023 Mar;19(3):292-300. doi: 10.1038/s41589-022-01154-9. Epub 2022 Oct 24. Nat Chem Biol. 2023. PMID: 36280791 Free PMC article.
Extended ubiquitin species are protein-based DUB inhibitors.
Krutauz D, Reis N, Nakasone MA, Siman P, Zhang D, Kirkpatrick DS, Gygi SP, Brik A, Fushman D, Glickman MH. Krutauz D, et al. Among authors: nakasone ma. Nat Chem Biol. 2014 Aug;10(8):664-70. doi: 10.1038/nchembio.1574. Epub 2014 Jul 6. Nat Chem Biol. 2014. PMID: 24997605 Free PMC article.
Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway.
Nakasone MA, Lewis TA, Walker O, Thakur A, Mansour W, Castañeda CA, Goeckeler-Fried JL, Parlati F, Chou TF, Hayat O, Zhang D, Camara CM, Bonn SM, Nowicka UK, Krueger S, Glickman MH, Brodsky JL, Deshaies RJ, Fushman D. Nakasone MA, et al. Structure. 2017 Dec 5;25(12):1839-1855.e11. doi: 10.1016/j.str.2017.10.007. Epub 2017 Nov 16. Structure. 2017. PMID: 29153505 Free PMC article.
Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit.
Chojnacki M, Mansour W, Hameed DS, Singh RK, El Oualid F, Rosenzweig R, Nakasone MA, Yu Z, Glaser F, Kay LE, Fushman D, Ovaa H, Glickman MH. Chojnacki M, et al. Among authors: nakasone ma. Cell Chem Biol. 2017 Apr 20;24(4):443-457.e6. doi: 10.1016/j.chembiol.2017.02.013. Epub 2017 Mar 16. Cell Chem Biol. 2017. PMID: 28330605 Free PMC article.
17 results