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Aberrant miR-29 is a predictive feature of severe phenotypes in pediatric Crohn's disease.
Shumway AJ, Shanahan MT, Hollville E, Chen K, Beasley C, Villanueva JW, Albert S, Lian G, Cure MR, Schaner M, Zhu LC, Bantumilli S, Deshmukh M, Furey TS, Sheikh SZ, Sethupathy P. Shumway AJ, et al. Among authors: sheikh sz. JCI Insight. 2024 Feb 22;9(4):e168800. doi: 10.1172/jci.insight.168800. JCI Insight. 2024. PMID: 38385744 Free PMC article.
Alterations to chromatin in intestinal macrophages link IL-10 deficiency to inappropriate inflammatory responses.
Simon JM, Davis JP, Lee SE, Schaner MR, Gipson GR, Weiser M, Sartor RB, Herfarth HH, Rahbar R, Sadiq TS, Koruda MJ, McGovern DP, Lieb JD, Mohlke KL, Furey TS, Sheikh SZ. Simon JM, et al. Among authors: sheikh sz. Eur J Immunol. 2016 Aug;46(8):1912-25. doi: 10.1002/eji.201546237. Epub 2016 Jun 1. Eur J Immunol. 2016. PMID: 27159132 Free PMC article.
Molecular classification of Crohn's disease reveals two clinically relevant subtypes.
Weiser M, Simon JM, Kochar B, Tovar A, Israel JW, Robinson A, Gipson GR, Schaner MS, Herfarth HH, Sartor RB, McGovern DPB, Rahbar R, Sadiq TS, Koruda MJ, Furey TS, Sheikh SZ. Weiser M, et al. Among authors: sheikh sz. Gut. 2018 Jan;67(1):36-42. doi: 10.1136/gutjnl-2016-312518. Epub 2016 Oct 14. Gut. 2018. PMID: 27742763 Free PMC article.
Colonic epithelial miR-31 associates with the development of Crohn's phenotypes.
Keith BP, Barrow JB, Toyonaga T, Kazgan N, O'Connor MH, Shah ND, Schaner MS, Wolber EA, Trad OK, Gipson GR, Pitman WA, Kanke M, Saxena SJ, Chaumont N, Sadiq TS, Koruda MJ, Cotney PA, Allbritton N, Trembath DG, Sylvester F, Furey TS, Sethupathy P, Sheikh SZ. Keith BP, et al. Among authors: sheikh sz. JCI Insight. 2018 Oct 4;3(19):e122788. doi: 10.1172/jci.insight.122788. JCI Insight. 2018. PMID: 30282822 Free PMC article.
Redefining the IBDs using genome-scale molecular phenotyping.
Furey TS, Sethupathy P, Sheikh SZ. Furey TS, et al. Among authors: sheikh sz. Nat Rev Gastroenterol Hepatol. 2019 May;16(5):296-311. doi: 10.1038/s41575-019-0118-x. Nat Rev Gastroenterol Hepatol. 2019. PMID: 30787446 Free PMC article. Review.
Crohn's Disease Differentially Affects Region-Specific Composition and Aerotolerance Profiles of Mucosally Adherent Bacteria.
Shahir NM, Wang JR, Wolber EA, Schaner MS, Frank DN, Ir D, Robertson CE, Chaumont N, Sadiq TS, Koruda MJ, Rahbar R, Nix BD, Newberry RD, Sartor RB, Sheikh SZ, Furey TS. Shahir NM, et al. Among authors: sheikh sz. Inflamm Bowel Dis. 2020 Nov 19;26(12):1843-1855. doi: 10.1093/ibd/izaa103. Inflamm Bowel Dis. 2020. PMID: 32469069 Free PMC article.
Decreased Colonic Activin Receptor-Like Kinase 1 Disrupts Epithelial Barrier Integrity in Patients With Crohn's Disease.
Toyonaga T, Steinbach EC, Keith BP, Barrow JB, Schaner MR, Wolber EA, Beasley C, Huling J, Wang Y, Allbritton NL, Chaumont N, Sadiq TS, Koruda MJ, Jain A, Long MD, Barnes EL, Herfarth HH, Isaacs KL, Hansen JJ, Shanahan MT, Rahbar R, Furey TS, Sethupathy P, Sheikh SZ. Toyonaga T, et al. Among authors: sheikh sz. Cell Mol Gastroenterol Hepatol. 2020;10(4):779-796. doi: 10.1016/j.jcmgh.2020.06.005. Epub 2020 Jun 16. Cell Mol Gastroenterol Hepatol. 2020. PMID: 32561494 Free PMC article.
Increased Colonic Expression of ACE2 Associates with Poor Prognosis in Crohn's disease.
Toyonaga T, Araba KC, Kennedy MM, Keith BP, Wolber EA, Beasley C, Steinbach EC, Schaner MR, Jain A, Long MD, Barnes EL, Herfarth HH, Isaacs KL, Hansen JJ, Kapadia M, Gaston Guillem J, Koruda MJ, Rahbar R, Sadiq T, Gulati AS, Sethupathy P, Furey TS, Ehre C, Sheikh SZ. Toyonaga T, et al. Among authors: sheikh sz. bioRxiv [Preprint]. 2020 Nov 24:2020.11.24.396382. doi: 10.1101/2020.11.24.396382. bioRxiv. 2020. PMID: 33269348 Free PMC article. Updated. Preprint.
69 results