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Integrating High-Resolution Mass Spectral Data, Bioassays and Computational Models to Annotate Bioactives in Botanical Extracts: Case Study Analysis of C. asiatica Extract Associates Dicaffeoylquinic Acids with Protection against Amyloid-β Toxicity.
Alcázar Magaña A, Vaswani A, Brown KS, Jiang Y, Alam MN, Caruso M, Lak P, Cheong P, Gray NE, Quinn JF, Soumyanath A, Stevens JF, Maier CS. Alcázar Magaña A, et al. Molecules. 2024 Feb 13;29(4):838. doi: 10.3390/molecules29040838. Molecules. 2024. PMID: 38398590 Free PMC article.
Bioanalytical method validation and application to a phase 1, double-blind, randomized pharmacokinetic trial of a standardized Centella asiatica (L.) Urban water extract product in healthy older adults.
Wright KM, Bollen M, David J, Mepham B, Alcázar Magaña A, McClure C, Maier CS, Quinn JF, Soumyanath A. Wright KM, et al. Among authors: alcazar magana a. Front Pharmacol. 2023 Aug 23;14:1228030. doi: 10.3389/fphar.2023.1228030. eCollection 2023. Front Pharmacol. 2023. PMID: 37680716 Free PMC article.
Computation-Assisted Identification of Bioactive Compounds in Botanical Extracts: A Case Study of Anti-Inflammatory Natural Products from Hops.
Brown KS, Jamieson P, Wu W, Vaswani A, Alcazar Magana A, Choi J, Mattio LM, Cheong PH, Nelson D, Reardon PN, Miranda CL, Maier CS, Stevens JF. Brown KS, et al. Among authors: alcazar magana a. Antioxidants (Basel). 2022 Jul 19;11(7):1400. doi: 10.3390/antiox11071400. Antioxidants (Basel). 2022. PMID: 35883889 Free PMC article.
Pharmacokinetics and Pharmacodynamics of Key Components of a Standardized Centella asiatica Product in Cognitively Impaired Older Adults: A Phase 1, Double-Blind, Randomized Clinical Trial.
Wright KM, Bollen M, David J, Speers AB, Brandes MS, Gray NE, Alcázar Magaña A, McClure C, Stevens JF, Maier CS, Quinn JF, Soumyanath A. Wright KM, et al. Among authors: alcazar magana a. Antioxidants (Basel). 2022 Jan 23;11(2):215. doi: 10.3390/antiox11020215. Antioxidants (Basel). 2022. PMID: 35204098 Free PMC article.
Xanthohumol Pyrazole Derivative Improves Diet-Induced Obesity and Induces Energy Expenditure in High-Fat Diet-Fed Mice.
Paraiso IL, Mattio LM, Alcázar Magaña A, Choi J, Plagmann LS, Redick MA, Miranda CL, Maier CS, Dallavalle S, Kioussi C, Blakemore PR, Stevens JF. Paraiso IL, et al. Among authors: alcazar magana a. ACS Pharmacol Transl Sci. 2021 Nov 4;4(6):1782-1793. doi: 10.1021/acsptsci.1c00161. eCollection 2021 Dec 10. ACS Pharmacol Transl Sci. 2021. PMID: 34927010 Free PMC article.
19 results