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An in vivo duck hepatitis B virus model recapitulates key aspects of nucleic acid polymer treatment outcomes in chronic hepatitis B patients.
Antiviral Res. 2024 Apr;224:105835. doi: 10.1016/j.antiviral.2024.105835. Epub 2024 Feb 23.
Antiviral Res. 2024.
PMID: 38401714
Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles.
Vanrusselt H, Kum DB, Taverniti V, Liu C, Acosta Sanchez A, Corthout N, Munck S, Baumert TF, Beigelman L, Blatt LM, Symons JA, Deval J, Raboisson P, Verrier ER, Jekle A, Vendeville S, Debing Y.
Vanrusselt H, et al.
J Virol. 2023 Oct 31;97(10):e0072223. doi: 10.1128/jvi.00722-23. Epub 2023 Sep 27.
J Virol. 2023.
PMID: 37754761
Free PMC article.
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Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation.
Kum DB, Vanrusselt H, Acosta Sanchez A, Taverniti V, Verrier ER, Baumert TF, Liu C, Deval J, Corthout N, Munck S, Beigelman L, Blatt LM, Symons JA, Raboisson P, Jekle A, Vendeville S, Debing Y.
Kum DB, et al. Among authors: vanrusselt h.
Hepatology. 2023 Oct 1;78(4):1252-1265. doi: 10.1097/HEP.0000000000000428. Epub 2023 Apr 28.
Hepatology. 2023.
PMID: 37102495
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CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia.
Lodder C, Scheyltjens I, Stancu IC, Botella Lucena P, Gutiérrez de Ravé M, Vanherle S, Vanmierlo T, Cremers N, Vanrusselt H, Brône B, Hanseeuw B, Octave JN, Bottelbergs A, Movahedi K, Dewachter I.
Lodder C, et al. Among authors: vanrusselt h.
Acta Neuropathol Commun. 2021 Jun 8;9(1):108. doi: 10.1186/s40478-021-01204-8.
Acta Neuropathol Commun. 2021.
PMID: 34103079
Free PMC article.
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Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo.
Stancu IC, Cremers N, Vanrusselt H, Couturier J, Vanoosthuyse A, Kessels S, Lodder C, Brône B, Huaux F, Octave JN, Terwel D, Dewachter I.
Stancu IC, et al. Among authors: vanrusselt h.
Acta Neuropathol. 2019 Apr;137(4):599-617. doi: 10.1007/s00401-018-01957-y. Epub 2019 Feb 5.
Acta Neuropathol. 2019.
PMID: 30721409
Free PMC article.
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