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Repurposing DNase I and alginate lyase to degrade the biofilm matrix of dual-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa grown in artificial sputum medium: In-vitro assessment of their activity in combination with broad-spectrum antibiotics.
Wang Z, Vanbever R, Lorent JH, Solis J, Knoop C, Van Bambeke F. Wang Z, et al. Among authors: lorent jh. J Cyst Fibros. 2024 Feb 23:S1569-1993(24)00027-4. doi: 10.1016/j.jcf.2024.02.012. Online ahead of print. J Cyst Fibros. 2024. PMID: 38402083
Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism.
Jekhmane S, Derks MGN, Maity S, Slingerland CJ, Tehrani KHME, Medeiros-Silva J, Charitou V, Ammerlaan D, Fetz C, Consoli NA, Cochrane RVK, Matheson EJ, van der Weijde M, Elenbaas BOW, Lavore F, Cox R, Lorent JH, Baldus M, Künzler M, Lelli M, Cochrane SA, Martin NI, Roos WH, Breukink E, Weingarth M. Jekhmane S, et al. Among authors: lorent jh. Nat Microbiol. 2024 May 23. doi: 10.1038/s41564-024-01696-9. Online ahead of print. Nat Microbiol. 2024. PMID: 38783023
Metabolic labeling of the bacterial peptidoglycan by functionalized glucosamine.
Xu Y, Hernández-Rocamora VM, Lorent JH, Cox R, Wang X, Bao X, Stel M, Vos G, van den Bos RM, Pieters RJ, Gray J, Vollmer W, Breukink E. Xu Y, et al. Among authors: lorent jh. iScience. 2022 Jul 12;25(8):104753. doi: 10.1016/j.isci.2022.104753. eCollection 2022 Aug 19. iScience. 2022. PMID: 35942089 Free PMC article.
Teixobactin kills bacteria by a two-pronged attack on the cell envelope.
Shukla R, Lavore F, Maity S, Derks MGN, Jones CR, Vermeulen BJA, Melcrová A, Morris MA, Becker LM, Wang X, Kumar R, Medeiros-Silva J, van Beekveld RAM, Bonvin AMJJ, Lorent JH, Lelli M, Nowick JS, MacGillavry HD, Peoples AJ, Spoering AL, Ling LL, Hughes DE, Roos WH, Breukink E, Lewis K, Weingarth M. Shukla R, et al. Among authors: lorent jh. Nature. 2022 Aug;608(7922):390-396. doi: 10.1038/s41586-022-05019-y. Epub 2022 Aug 3. Nature. 2022. PMID: 35922513 Free PMC article.
Multifaceted Activities of Seven Nanobodies against Complement C4b.
De la O Becerra KI, Oosterheert W, van den Bos RM, Xenaki KT, Lorent JH, Ruyken M, Schouten A, Rooijakkers SHM, van Bergen En Henegouwen PMP, Gros P. De la O Becerra KI, et al. Among authors: lorent jh. J Immunol. 2022 May 1;208(9):2207-2219. doi: 10.4049/jimmunol.2100647. Epub 2022 Apr 15. J Immunol. 2022. PMID: 35428691 Free PMC article.
22 results