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Host-Microbe Multiomic Profiling Reveals Age-Dependent COVID-19 Immunopathology.
Van Phan H, Tsitsiklis A, Maguire CP, Haddad EK, Becker PM, Kim-Schulze S, Lee B, Chen J, Hoch A, Pickering H, Van Zalm P, Altman MC, Augustine AD, Calfee CS, Bosinger S, Cairns C, Eckalbar W, Guan L, Jayavelu ND, Kleinstein SH, Krammer F, Maecker HT, Ozonoff A, Peters B, Rouphael N; IMPACC Network; Montgomery RR, Reed E, Schaenman J, Steen H, Levy O, Diray-Arce J, Langelier CR. Van Phan H, et al. Among authors: kleinstein sh. medRxiv [Preprint]. 2024 Feb 13:2024.02.11.24301704. doi: 10.1101/2024.02.11.24301704. medRxiv. 2024. PMID: 38405760 Free PMC article. Updated. Preprint.
nf-core/airrflow: an adaptive immune receptor repertoire analysis workflow employing the Immcantation framework.
Gabernet G, Marquez S, Bjornson R, Peltzer A, Meng H, Aron E, Lee NY, Jensen C, Ladd D, Hanssen F, Heumos S; nf-core community; Yaari G, Kowarik MC, Nahnsen S, Kleinstein SH. Gabernet G, et al. Among authors: kleinstein sh. bioRxiv [Preprint]. 2024 Jan 28:2024.01.18.576147. doi: 10.1101/2024.01.18.576147. bioRxiv. 2024. PMID: 38293151 Free PMC article. Preprint.
Integrated longitudinal multiomics study identifies immune programs associated with acute COVID-19 severity and mortality.
Gygi JP, Maguire C, Patel RK, Shinde P, Konstorum A, Shannon CP, Xu L, Hoch A, Jayavelu ND, Haddad EK; IMPACC Network; Reed EF, Kraft M, McComsey GA, Metcalf JP, Ozonoff A, Esserman D, Cairns CB, Rouphael N, Bosinger SE, Kim-Schulze S, Krammer F, Rosen LB, van Bakel H, Wilson M, Eckalbar WL, Maecker HT, Langelier CR, Steen H, Altman MC, Montgomery RR, Levy O, Melamed E, Pulendran B, Diray-Arce J, Smolen KK, Fragiadakis GK, Becker PM, Sekaly RP, Ehrlich LI, Fourati S, Peters B, Kleinstein SH, Guan L. Gygi JP, et al. Among authors: kleinstein sh. J Clin Invest. 2024 May 1;134(9):e176640. doi: 10.1172/JCI176640. J Clin Invest. 2024. PMID: 38690733 Free PMC article. Clinical Trial.
Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology.
Phan HV, Tsitsiklis A, Maguire CP, Haddad EK, Becker PM, Kim-Schulze S, Lee B, Chen J, Hoch A, Pickering H, van Zalm P, Altman MC, Augustine AD, Calfee CS, Bosinger S, Cairns CB, Eckalbar W, Guan L, Jayavelu ND, Kleinstein SH, Krammer F, Maecker HT, Ozonoff A, Peters B, Rouphael N; IMPACC Network; Montgomery RR, Reed E, Schaenman J, Steen H, Levy O, Diray-Arce J, Langelier CR. Phan HV, et al. Among authors: kleinstein sh. Sci Transl Med. 2024 Apr 17;16(743):eadj5154. doi: 10.1126/scitranslmed.adj5154. Epub 2024 Apr 17. Sci Transl Med. 2024. PMID: 38630846
A multi-omics systems vaccinology resource to develop and test computational models of immunity.
Shinde P, Soldevila F, Reyna J, Aoki M, Rasmussen M, Willemsen L, Kojima M, Ha B, Greenbaum JA, Overton JA, Guzman-Orozco H, Nili S, Orfield S, Gygi JP, da Silva Antunes R, Sette A, Grant B, Olsen LR, Konstorum A, Guan L, Ay F, Kleinstein SH, Peters B. Shinde P, et al. Among authors: kleinstein sh. Cell Rep Methods. 2024 Mar 25;4(3):100731. doi: 10.1016/j.crmeth.2024.100731. Epub 2024 Mar 14. Cell Rep Methods. 2024. PMID: 38490204 Free PMC article.
CD23+IgG1+ memory B cells are poised to switch to pathogenic IgE production in food allergy.
Ota M, Hoehn KB, Fernandes-Braga W, Ota T, Aranda CJ, Friedman S, Miranda-Waldetario MGC, Redes J, Suprun M, Grishina G, Sampson HA, Malbari A, Kleinstein SH, Sicherer SH, Curotto de Lafaille MA. Ota M, et al. Among authors: kleinstein sh. Sci Transl Med. 2024 Feb 7;16(733):eadi0673. doi: 10.1126/scitranslmed.adi0673. Epub 2024 Feb 7. Sci Transl Med. 2024. PMID: 38324641 Free PMC article.
IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition.
Haslund-Gourley BS, Woloszczuk K, Hou J, Connors J, Cusimano G, Bell M, Taramangalam B, Fourati S, Mege N, Bernui M, Altman MC, Krammer F, van Bakel H; IMPACC Network; Maecker HT, Rouphael N, Diray-Arce J, Wigdahl B, Kutzler MA, Cairns CB, Haddad EK, Comunale MA. Haslund-Gourley BS, et al. Nat Commun. 2024 Jan 9;15(1):404. doi: 10.1038/s41467-023-44211-0. Nat Commun. 2024. PMID: 38195739 Free PMC article.
Author Correction: Mapping disease regulatory circuits at cell-type resolution from single-cell multiomics data.
Chen X, Wang Y, Cappuccio A, Cheng WS, Zamojski FR, Nair VD, Miller CM, Rubenstein AB, Nudelman G, Tadych A, Theesfeld CL, Vornholt A, George MC, Ruffin F, Dagher M, Chawla DG, Soares-Schanoski A, Spurbeck RR, Ndhlovu LC, Sebra R, Kleinstein SH, Letizia AG, Ramos I, Fowler VG Jr, Woods CW, Zaslavsky E, Troyanskaya OG, Sealfon SC. Chen X, et al. Among authors: kleinstein sh. Nat Comput Sci. 2023 Sep;3(9):805. doi: 10.1038/s43588-023-00523-1. Nat Comput Sci. 2023. PMID: 38177788 Free PMC article. No abstract available.
183 results