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The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology.
Linnerbauer M, Lößlein L, Vandrey O, Peter A, Han Y, Tsaktanis T, Wogram E, Needhamsen M, Kular L, Nagel L, Zissler J, Andert M, Meszaros L, Hanspach J, Zuber F, Naumann UJ, Diebold M, Wheeler MA, Beyer T, Nirschl L, Cirac A, Laun FB, Günther C, Winkler J, Bäuerle T, Jagodic M, Hemmer B, Prinz M, Quintana FJ, Rothhammer V. Linnerbauer M, et al. Among authors: nirschl l. Nat Immunol. 2024 Mar;25(3):432-447. doi: 10.1038/s41590-024-01756-6. Epub 2024 Feb 26. Nat Immunol. 2024. PMID: 38409259 Free PMC article.
B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4.
Afzali AM, Nirschl L, Sie C, Pfaller M, Ulianov O, Hassler T, Federle C, Petrozziello E, Kalluri SR, Chen HH, Tyystjärvi S, Muschaweckh A, Lammens K, Delbridge C, Büttner A, Steiger K, Seyhan G, Ottersen OP, Öllinger R, Rad R, Jarosch S, Straub A, Mühlbauer A, Grassmann S, Hemmer B, Böttcher JP, Wagner I, Kreutzfeldt M, Merkler D, Pardàs IB, Schmidt Supprian M, Buchholz VR, Heink S, Busch DH, Klein L, Korn T. Afzali AM, et al. Among authors: nirschl l. Nature. 2024 Mar;627(8003):407-415. doi: 10.1038/s41586-024-07079-8. Epub 2024 Feb 21. Nature. 2024. PMID: 38383779 Free PMC article.
PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation.
Linnerbauer M, Beyer T, Nirschl L, Farrenkopf D, Lößlein L, Vandrey O, Peter A, Tsaktanis T, Kebir H, Laplaud D, Oellinger R, Engleitner T, Alvarez JI, Rad R, Korn T, Hemmer B, Quintana FJ, Rothhammer V. Linnerbauer M, et al. Among authors: nirschl l. Nat Commun. 2023 Sep 9;14(1):5555. doi: 10.1038/s41467-023-40982-8. Nat Commun. 2023. PMID: 37689786 Free PMC article.
Regulation of the programmed cell death protein 1/programmed cell death ligand 1 axis in relapsing-remitting multiple sclerosis.
Tsaktanis T, Linnerbauer M, Lößlein L, Farrenkopf D, Vandrey O, Peter A, Cirac A, Beyer T, Nirschl L, Grummel V, Mühlau M, Bussas M, Hemmer B, Quintana FJ, Rothhammer V. Tsaktanis T, et al. Among authors: nirschl l. Brain Commun. 2023 Jul 25;5(4):fcad206. doi: 10.1093/braincomms/fcad206. eCollection 2023. Brain Commun. 2023. PMID: 37564830 Free PMC article.
IL-24 intrinsically regulates Th17 cell pathogenicity in mice.
Sie C, Kant R, Peter C, Muschaweckh A, Pfaller M, Nirschl L, Moreno HD, Chadimová T, Lepennetier G, Kuhlmann T, Öllinger R, Engleitner T, Rad R, Korn T. Sie C, et al. Among authors: nirschl l. J Exp Med. 2022 Aug 1;219(8):e20212443. doi: 10.1084/jem.20212443. Epub 2022 Jul 12. J Exp Med. 2022. PMID: 35819408 Free PMC article.
The Aryl Hydrocarbon Receptor-Dependent TGF-α/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis.
Cirac A, Tsaktanis T, Beyer T, Linnerbauer M, Andlauer T, Grummel V, Nirschl L, Loesslein L, Quintana FJ, Hemmer B, Rothhammer V. Cirac A, et al. Among authors: nirschl l. Neurol Neuroimmunol Neuroinflamm. 2021 Jul 23;8(5):e1043. doi: 10.1212/NXI.0000000000001043. Print 2021 Jul. Neurol Neuroimmunol Neuroinflamm. 2021. PMID: 34301821 Free PMC article.
Aryl Hydrocarbon Receptor Plasma Agonist Activity Correlates With Disease Activity in Progressive MS.
Tsaktanis T, Beyer T, Nirschl L, Linnerbauer M, Grummel V, Bussas M, Tjon E, Mühlau M, Korn T, Hemmer B, Quintana FJ, Rothhammer V. Tsaktanis T, et al. Among authors: nirschl l. Neurol Neuroimmunol Neuroinflamm. 2020 Dec 24;8(2):e933. doi: 10.1212/NXI.0000000000000933. Print 2021 Mar. Neurol Neuroimmunol Neuroinflamm. 2020. PMID: 33361385 Free PMC article.