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Loss of NAT10 disrupts enhancer organization via p300 mislocalization and suppresses transcription of genes necessary for metastasis progression.
Amin R, Ha NH, Qiu T, Holewinski R, Lam KC, Lopès A, Liu H, Tran AD, Lee MP, Gamage ST, Andresson T, Goldszmid RS, Meier JL, Hunter KW. Amin R, et al. Among authors: meier jl. bioRxiv [Preprint]. 2024 Jan 29:2024.01.24.577116. doi: 10.1101/2024.01.24.577116. bioRxiv. 2024. PMID: 38410432 Free PMC article. Preprint.
Molecular Basis for RNA Cytidine Acetylation by NAT10.
Zhou M, Gamage ST, Tran KA, Bartee D, Wei X, Yin B, Berger S, Meier JL, Marmorstein R. Zhou M, et al. Among authors: meier jl. bioRxiv [Preprint]. 2024 Mar 27:2024.03.27.587050. doi: 10.1101/2024.03.27.587050. bioRxiv. 2024. PMID: 38585770 Free PMC article. Preprint.
Paralogue-selective degradation of the lysine acetyltransferase EP300.
Chen X, Crawford MC, Xiong Y, Shaik AB, Suazo KF, Penkalapati MS, Williams JH, Andressen T, Swenson RE, Meier JL. Chen X, et al. Among authors: meier jl. bioRxiv [Preprint]. 2024 May 5:2024.05.03.592353. doi: 10.1101/2024.05.03.592353. bioRxiv. 2024. PMID: 38746397 Free PMC article. Preprint.
A Phase 2 Clinical Trial to Evaluate the Safety, Reactogenicity, and Immunogenicity of Different Prime-Boost Vaccination Schedules of 2013 and 2017 A(H7N9) Inactivated Influenza Virus Vaccines Administered with and without AS03 Adjuvant in Healthy US Adults.
Rostad CA, Atmar RL, Walter EB, Frey S, Meier JL, Sherman AC, Lai L, Tsong R, Kao CM, Raabe V, El Sahly HM, Keitel WA, Whitaker JA, Smith MJ, Schmader KE, Swamy GK, Abate G, Winokur P, Buchanan W, Cross K, Wegel A, Xu Y, Yildirim I, Kamidani S, Rouphael N, Roberts PC, Mulligan MJ, Anderson EJ. Rostad CA, et al. Among authors: meier jl. Clin Infect Dis. 2024 Mar 27:ciae173. doi: 10.1093/cid/ciae173. Online ahead of print. Clin Infect Dis. 2024. PMID: 38537255
Rewiring of RNA methylation by the oncometabolite fumarate in renal cell carcinoma.
Fitzsimmons CM, Mandler MD, Lunger JC, Chan D, Maligireddy SS, Schmiechen AC, Gamage ST, Link C, Jenkins LM, Chan K, Andresson T, Crooks DR, Meier JL, Linehan WM, Batista PJ. Fitzsimmons CM, et al. Among authors: meier jl. NAR Cancer. 2024 Feb 7;6(1):zcae004. doi: 10.1093/narcan/zcae004. eCollection 2024 Mar. NAR Cancer. 2024. PMID: 38328795 Free PMC article.
Cytidine Acetylation Across the Tree of Life.
Thalalla Gamage S, Howpay Manage SA, Chu TT, Meier JL. Thalalla Gamage S, et al. Among authors: meier jl. Acc Chem Res. 2024 Feb 6;57(3):338-348. doi: 10.1021/acs.accounts.3c00673. Epub 2024 Jan 16. Acc Chem Res. 2024. PMID: 38226431
Comparative Analysis of Drug-like EP300/CREBBP Acetyltransferase Inhibitors.
Crawford MC, Tripu DR, Barritt SA, Jing Y, Gallimore D, Kales SC, Bhanu NV, Xiong Y, Fang Y, Butler KAT, LeClair CA, Coussens NP, Simeonov A, Garcia BA, Dibble CC, Meier JL. Crawford MC, et al. Among authors: meier jl. ACS Chem Biol. 2023 Oct 20;18(10):2249-2258. doi: 10.1021/acschembio.3c00293. Epub 2023 Sep 22. ACS Chem Biol. 2023. PMID: 37737090 Free PMC article.
Cryptic splice mutation in the fumarate hydratase gene in patients with clinical manifestations of Hereditary Leiomyomatosis and Renal Cell Cancer.
Crooks DR, Cawthon GM, Fitzsimmons CM, Perez M, Ricketts CJ, Vocke CD, Yang Y, Middelton L, Nielsen D, Schmidt LS, Tandon M, Merino MJ, Ball MW, Meier JL, Batista PJ, Linehan WM. Crooks DR, et al. Among authors: meier jl. Hum Mol Genet. 2023 Nov 3;32(22):3135-3145. doi: 10.1093/hmg/ddad131. Hum Mol Genet. 2023. PMID: 37561409
Chemoproteomics Yields a Selective Molecular Host for Acetyl-CoA.
Lieberman WK, Brown ZA, Kantner DS, Jing Y, Megill E, Evans ND, Crawford MC, Jhulki I, Grose C, Jones JE, Snyder NW, Meier JL. Lieberman WK, et al. Among authors: meier jl. J Am Chem Soc. 2023 Aug 2;145(30):16899-16905. doi: 10.1021/jacs.3c05489. Epub 2023 Jul 24. J Am Chem Soc. 2023. PMID: 37486078
182 results