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Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts.
Wani A, Katrinli S, Zhao X, Daskalakis N, Zannas A, Aiello A, Baker D, Boks M, Brick L, Chen CY, Dalvie S, Fortier C, Geuze E, Hayes J, Kessler R, King A, Koen N, Liberzon I, Lori A, Luykx J, Maihofer A, Milberg W, Miller M, Mufford M, Nugent N, Rauch S, Ressler K, Risbrough V, Rutten B, Stein D, Stein M, Ursano R, Verfaellie M, Ware E, Wildman D, Wolf E, Nievergelt C, Logue M, Smith A, Uddin M, Vermetten E, Vinkers C. Wani A, et al. Res Sq [Preprint]. 2024 Feb 15:rs.3.rs-3952163. doi: 10.21203/rs.3.rs-3952163/v1. Res Sq. 2024. PMID: 38410438 Free PMC article. Preprint.
Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR.
Smith AK, Ratanatharathorn A, Maihofer AX, Naviaux RK, Aiello AE, Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Boks MP, Bromet E, Dennis M, Galea S, Garrett ME, Geuze E, Guffanti G, Hauser MA, Katrinli S, Kilaru V, Kessler RC, Kimbrel NA, Koenen KC, Kuan PF, Li K, Logue MW, Lori A, Luft BJ, Miller MW, Naviaux JC, Nugent NR, Qin X, Ressler KJ, Risbrough VB, Rutten BPF, Stein MB, Ursano RJ, Vermetten E, Vinkers CH, Wang L, Youssef NA; INTRuST Clinical Consortium; VA Mid-Atlantic MIRECC Workgroup; PGC PTSD Epigenetics Workgroup; Uddin M, Nievergelt CM. Smith AK, et al. Nat Commun. 2020 Nov 24;11(1):5965. doi: 10.1038/s41467-020-19615-x. Nat Commun. 2020. PMID: 33235198 Free PMC article.
Epigenome-wide meta-analysis of PTSD symptom severity in three military cohorts implicates DNA methylation changes in genes involved in immune system and oxidative stress.
Katrinli S, Maihofer AX, Wani AH, Pfeiffer JR, Ketema E, Ratanatharathorn A, Baker DG, Boks MP, Geuze E, Kessler RC, Risbrough VB, Rutten BPF, Stein MB, Ursano RJ, Vermetten E, Logue MW, Nievergelt CM, Smith AK, Uddin M. Katrinli S, et al. Among authors: wani ah. Mol Psychiatry. 2022 Mar;27(3):1720-1728. doi: 10.1038/s41380-021-01398-2. Epub 2022 Jan 7. Mol Psychiatry. 2022. PMID: 34992238 Free PMC article.
DNA methylation of Nuclear Factor of Activated T Cells 1 mediates the prospective relation between exposure to different traumatic event types and post-traumatic stress disorder.
Occean JR, Wani AH, Donglasan J, Aiello AE, Galea S, Koenen KC, Qu A, Wildman DE, Uddin M. Occean JR, et al. Among authors: wani ah. Psychiatry Res. 2022 May;311:114510. doi: 10.1016/j.psychres.2022.114510. Epub 2022 Mar 19. Psychiatry Res. 2022. PMID: 35349860 Free PMC article.
Evaluating the impact of trauma and PTSD on epigenetic prediction of lifespan and neural integrity.
Katrinli S, Stevens J, Wani AH, Lori A, Kilaru V, van Rooij SJH, Hinrichs R, Powers A, Gillespie CF, Michopoulos V, Gautam A, Jett M, Hammamieh R, Yang R, Wildman D, Qu A, Koenen K, Aiello AE, Jovanovic T, Uddin M, Ressler KJ, Smith AK. Katrinli S, et al. Among authors: wani ah. Neuropsychopharmacology. 2020 Sep;45(10):1609-1616. doi: 10.1038/s41386-020-0700-5. Epub 2020 May 7. Neuropsychopharmacology. 2020. PMID: 32380512 Free PMC article.
RANDOMIZE: A Web Server for Data Randomization.
Wani AH, Armstrong D, Dahrendorff J, Uddin M. Wani AH, et al. Arch Proteom Bioinform. 2020;1(1):31-37. Arch Proteom Bioinform. 2020. PMID: 33554223 Free PMC article.
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.
Meng X, Navoly G, Giannakopoulou O, Levey DF, Koller D, Pathak GA, Koen N, Lin K, Adams MJ, Rentería ME, Feng Y, Gaziano JM, Stein DJ, Zar HJ, Campbell ML, van Heel DA, Trivedi B, Finer S, McQuillin A, Bass N, Chundru VK, Martin HC, Huang QQ, Valkovskaya M, Chu CY, Kanjira S, Kuo PH, Chen HC, Tsai SJ, Liu YL, Kendler KS, Peterson RE, Cai N, Fang Y, Sen S, Scott LJ, Burmeister M, Loos RJF, Preuss MH, Actkins KV, Davis LK, Uddin M, Wani AH, Wildman DE, Aiello AE, Ursano RJ, Kessler RC, Kanai M, Okada Y, Sakaue S, Rabinowitz JA, Maher BS, Uhl G, Eaton W, Cruz-Fuentes CS, Martinez-Levy GA, Campos AI, Millwood IY, Chen Z, Li L, Wassertheil-Smoller S, Jiang Y, Tian C, Martin NG, Mitchell BL, Byrne EM, Awasthi S, Coleman JRI, Ripke S; PGC-MDD Working Group; China Kadoorie Biobank Collaborative Group; 23andMe Research Team; Genes and Health Research Team; BioBank Japan Project; Sofer T, Walters RG, McIntosh AM, Polimanti R, Dunn EC, Stein MB, Gelernter J, Lewis CM, Kuchenbaecker K. Meng X, et al. Among authors: wani ah. Nat Genet. 2024 Feb;56(2):222-233. doi: 10.1038/s41588-023-01596-4. Epub 2024 Jan 4. Nat Genet. 2024. PMID: 38177345 Free PMC article.
597 results