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Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity.
Dong H, He X, Zhang L, Chen W, Lin YC, Liu SB, Wang H, Nguyen LXT, Li M, Zhu Y, Zhao D, Ghoda L, Serody J, Vincent B, Luznik L, Gojo I, Zeidner J, Su R, Chen J, Sharma R, Pirrotte P, Wu X, Hu W, Han W, Shen B, Kuo YH, Jin J, Salhotra A, Wang J, Marcucci G, Luo YL, Li L. Dong H, et al. Nat Cancer. 2024 Apr;5(4):601-624. doi: 10.1038/s43018-024-00736-x. Epub 2024 Feb 27. Nat Cancer. 2024. PMID: 38413714 Free PMC article.
PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+ acute myeloid leukemia.
He X, Zhu Y, Lin YC, Li M, Du J, Dong H, Sun J, Zhu L, Wang H, Ding Z, Zhang L, Zhang L, Zhao D, Wang Z, Wu H, Zhang H, Jiang W, Xu Y, Jin J, Shen Y, Perry J, Zhao X, Zhang B, Liu S, Xue SL, Shen B, Chen CW, Chen J, Khaled S, Kuo YH, Marcucci G, Luo Y, Li L. He X, et al. Among authors: dong h. Blood. 2019 Aug 8;134(6):548-560. doi: 10.1182/blood.2019001282. Epub 2019 Jun 19. Blood. 2019. PMID: 31217189 Free PMC article.
Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia.
Zhu Y, He X, Lin YC, Dong H, Zhang L, Chen X, Wang Z, Shen Y, Li M, Wang H, Sun J, Nguyen LX, Zhang H, Jiang W, Yang Y, Chen J, Müschen M, Chen CW, Konopleva MY, Sun W, Jin J, Carlesso N, Marcucci G, Luo Y, Li L. Zhu Y, et al. Among authors: dong h. Blood. 2019 Oct 10;134(15):1257-1268. doi: 10.1182/blood.2019002457. Blood. 2019. PMID: 31395602 Free PMC article.
Targeting miR-126 in inv(16) acute myeloid leukemia inhibits leukemia development and leukemia stem cell maintenance.
Zhang L, Nguyen LXT, Chen YC, Wu D, Cook GJ, Hoang DH, Brewer CJ, He X, Dong H, Li S, Li M, Zhao D, Qi J, Hua WK, Cai Q, Carnahan E, Chen W, Wu X, Swiderski P, Rockne RC, Kortylewski M, Li L, Zhang B, Marcucci G, Kuo YH. Zhang L, et al. Among authors: dong h. Nat Commun. 2021 Oct 22;12(1):6154. doi: 10.1038/s41467-021-26420-7. Nat Commun. 2021. PMID: 34686664 Free PMC article.
Disruption of dNTP homeostasis by ribonucleotide reductase hyperactivation overcomes AML differentiation blockade.
Wang H, He X, Zhang L, Dong H, Huang F, Xian J, Li M, Chen W, Lu X, Pathak KV, Huang W, Li Z, Zhang L, Nguyen LXT, Yang L, Feng L, Gordon DJ, Zhang J, Pirrotte P, Chen CW, Salhotra A, Kuo YH, Horne D, Marcucci G, Sykes DB, Tiziani S, Jin H, Wang X, Li L. Wang H, et al. Among authors: dong h. Blood. 2022 Jun 30;139(26):3752-3770. doi: 10.1182/blood.2021015108. Blood. 2022. PMID: 35439288 Free PMC article.
TET2 deficiency promotes MDS-associated leukemogenesis.
Huang F, Sun J, Chen W, Zhang L, He X, Dong H, Wu Y, Wang H, Li Z, Ball B, Khaled S, Marcucci G, Li L. Huang F, et al. Among authors: dong h. Blood Cancer J. 2022 Oct 4;12(10):141. doi: 10.1038/s41408-022-00739-w. Blood Cancer J. 2022. PMID: 36195586 Free PMC article. No abstract available.
Correction: TET2 deficiency promotes MDS-associated leukemogenesis.
Huang F, Sun J, Chen W, Zhang L, He X, Dong H, Wu Y, Wang H, Li Z, Ball B, Khaled S, Marcucci G, Li L. Huang F, et al. Among authors: dong h. Blood Cancer J. 2023 Nov 28;13(1):174. doi: 10.1038/s41408-023-00952-1. Blood Cancer J. 2023. PMID: 38016965 Free PMC article. No abstract available.
SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function.
Sun J, He X, Zhu Y, Ding Z, Dong H, Feng Y, Du J, Wang H, Wu X, Zhang L, Yu X, Lin A, McDonald T, Zhao D, Wu H, Hua WK, Zhang B, Feng L, Tohyama K, Bhatia R, Oberdoerffer P, Chung YJ, Aplan PD, Boultwood J, Pellagatti A, Khaled S, Kortylewski M, Pichiorri F, Kuo YH, Carlesso N, Marcucci G, Jin H, Li L. Sun J, et al. Among authors: dong h. Cell Stem Cell. 2018 Sep 6;23(3):355-369.e9. doi: 10.1016/j.stem.2018.07.018. Epub 2018 Aug 23. Cell Stem Cell. 2018. PMID: 30146412 Free PMC article.
Role of SIRT1 in hematologic malignancies.
Huang FT, Sun J, Zhang L, He X, Zhu YH, Dong HJ, Wang HY, Zhu L, Zou JY, Huang JW, Li L. Huang FT, et al. J Zhejiang Univ Sci B. 2019 May;20(5):391-398. doi: 10.1631/jzus.B1900148. J Zhejiang Univ Sci B. 2019. PMID: 31090265 Free PMC article. Review.
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