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2,578 results

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Page 1
On the genetic basis of tail-loss evolution in humans and apes.
Xia B, Zhang W, Zhao G, Zhang X, Bai J, Brosh R, Wudzinska A, Huang E, Ashe H, Ellis G, Pour M, Zhao Y, Coelho C, Zhu Y, Miller A, Dasen JS, Maurano MT, Kim SY, Boeke JD, Yanai I. Xia B, et al. Among authors: huang e. Nature. 2024 Feb;626(8001):1042-1048. doi: 10.1038/s41586-024-07095-8. Epub 2024 Feb 28. Nature. 2024. PMID: 38418917 Free PMC article.
A versatile platform for locus-scale genome rewriting and verification.
Brosh R, Laurent JM, Ordoñez R, Huang E, Hogan MS, Hitchcock AM, Mitchell LA, Pinglay S, Cadley JA, Luther RD, Truong DM, Boeke JD, Maurano MT. Brosh R, et al. Among authors: huang e. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2023952118. doi: 10.1073/pnas.2023952118. Proc Natl Acad Sci U S A. 2021. PMID: 33649239 Free PMC article.
De novo assembly and delivery to mouse cells of a 101 kb functional human gene.
Mitchell LA, McCulloch LH, Pinglay S, Berger H, Bosco N, Brosh R, Bulajić M, Huang E, Hogan MS, Martin JA, Mazzoni EO, Davoli T, Maurano MT, Boeke JD. Mitchell LA, et al. Among authors: huang e. Genetics. 2021 May 17;218(1):iyab038. doi: 10.1093/genetics/iyab038. Genetics. 2021. PMID: 33742653 Free PMC article.
Synthetic regulatory reconstitution reveals principles of mammalian Hox cluster regulation.
Pinglay S, Bulajić M, Rahe DP, Huang E, Brosh R, Mamrak NE, King BR, German S, Cadley JA, Rieber L, Easo N, Lionnet T, Mahony S, Maurano MT, Holt LJ, Mazzoni EO, Boeke JD. Pinglay S, et al. Among authors: huang e. Science. 2022 Jul;377(6601):eabk2820. doi: 10.1126/science.abk2820. Epub 2022 Jul 1. Science. 2022. PMID: 35771912 Free PMC article.
Synthetic regulatory genomics uncovers enhancer context dependence at the Sox2 locus.
Brosh R, Coelho C, Ribeiro-Dos-Santos AM, Ellis G, Hogan MS, Ashe HJ, Somogyi N, Ordoñez R, Luther RD, Huang E, Boeke JD, Maurano MT. Brosh R, et al. Among authors: huang e. Mol Cell. 2023 Apr 6;83(7):1140-1152.e7. doi: 10.1016/j.molcel.2023.02.027. Epub 2023 Mar 16. Mol Cell. 2023. PMID: 36931273 Free PMC article.
Genomic context sensitizes regulatory elements to genetic disruption.
Ordoñez R, Zhang W, Ellis G, Zhu Y, Ashe HJ, Ribeiro-Dos-Santos AM, Brosh R, Huang E, Hogan MS, Boeke JD, Maurano MT. Ordoñez R, et al. Among authors: huang e. bioRxiv [Preprint]. 2024 Mar 12:2023.07.02.547201. doi: 10.1101/2023.07.02.547201. bioRxiv. 2024. PMID: 37781588 Free PMC article. Updated. Preprint.
Genomic context sensitizes regulatory elements to genetic disruption.
Ordoñez R, Zhang W, Ellis G, Zhu Y, Ashe HJ, Ribeiro-Dos-Santos AM, Brosh R, Huang E, Hogan MS, Boeke JD, Maurano MT. Ordoñez R, et al. Among authors: huang e. Mol Cell. 2024 May 16;84(10):1842-1854.e7. doi: 10.1016/j.molcel.2024.04.013. Mol Cell. 2024. PMID: 38759624
Sequencing identifies multiple early introductions of SARS-CoV-2 to the New York City Region.
Maurano MT, Ramaswami S, Zappile P, Dimartino D, Boytard L, Ribeiro-Dos-Santos AM, Vulpescu NA, Westby G, Shen G, Feng X, Hogan MS, Ragonnet-Cronin M, Geidelberg L, Marier C, Meyn P, Zhang Y, Cadley J, Ordoñez R, Luther R, Huang E, Guzman E, Arguelles-Grande C, Argyropoulos KV, Black M, Serrano A, Call ME, Kim MJ, Belovarac B, Gindin T, Lytle A, Pinnell J, Vougiouklakis T, Chen J, Lin LH, Rapkiewicz A, Raabe V, Samanovic MI, Jour G, Osman I, Aguero-Rosenfeld M, Mulligan MJ, Volz EM, Cotzia P, Snuderl M, Heguy A. Maurano MT, et al. Among authors: huang e. medRxiv [Preprint]. 2020 Aug 19:2020.04.15.20064931. doi: 10.1101/2020.04.15.20064931. medRxiv. 2020. PMID: 32511587 Free PMC article. Updated. Preprint.
Sequencing identifies multiple early introductions of SARS-CoV-2 to the New York City region.
Maurano MT, Ramaswami S, Zappile P, Dimartino D, Boytard L, Ribeiro-Dos-Santos AM, Vulpescu NA, Westby G, Shen G, Feng X, Hogan MS, Ragonnet-Cronin M, Geidelberg L, Marier C, Meyn P, Zhang Y, Cadley J, Ordoñez R, Luther R, Huang E, Guzman E, Arguelles-Grande C, Argyropoulos KV, Black M, Serrano A, Call ME, Kim MJ, Belovarac B, Gindin T, Lytle A, Pinnell J, Vougiouklakis T, Chen J, Lin LH, Rapkiewicz A, Raabe V, Samanovic MI, Jour G, Osman I, Aguero-Rosenfeld M, Mulligan MJ, Volz EM, Cotzia P, Snuderl M, Heguy A. Maurano MT, et al. Among authors: huang e. Genome Res. 2020 Dec;30(12):1781-1788. doi: 10.1101/gr.266676.120. Epub 2020 Oct 22. Genome Res. 2020. PMID: 33093069 Free PMC article. Clinical Trial.
2,578 results