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Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus.
Chen W, Hong SH, Jenks SA, Anam FA, Tipton CM, Woodruff MC, Hom JR, Cashman KS, Faliti CE, Wang X, Kyu S, Wei C, Scharer CD, Mi T, Hicks S, Hartson L, Nguyen DC, Khosroshahi A, Lee S, Wang Y, Bugrovsky R, Ishii Y, Lee FE, Sanz I. Chen W, et al. Nat Commun. 2024 Mar 1;15(1):1899. doi: 10.1038/s41467-024-46053-w. Nat Commun. 2024. PMID: 38429276 Free PMC article.
SLE Antibody-Secreting Cells Are Characterized by Enhanced Peripheral Maturation and Survival Programs.
Chen W, Hong SH, Jenks SA, Anam FA, Tipton CM, Woodruff MC, Hom JR, Cashman KS, Faliti CE, Wang X, Kyu S, Wei C, Scharer CD, Mi T, Hicks S, Hartson L, Nguyen DC, Khosroshahi A, Lee S, Wang Y, Bugrovsky R, Ishii Y, Lee FE, Sanz I. Chen W, et al. Res Sq [Preprint]. 2023 Jun 27:rs.3.rs-3016327. doi: 10.21203/rs.3.rs-3016327/v1. Res Sq. 2023. PMID: 37461641 Free PMC article. Updated. Preprint.
Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19.
Woodruff MC, Ramonell RP, Nguyen DC, Cashman KS, Saini AS, Haddad NS, Ley AM, Kyu S, Howell JC, Ozturk T, Lee S, Suryadevara N, Case JB, Bugrovsky R, Chen W, Estrada J, Morrison-Porter A, Derrico A, Anam FA, Sharma M, Wu HM, Le SN, Jenks SA, Tipton CM, Staitieh B, Daiss JL, Ghosn E, Diamond MS, Carnahan RH, Crowe JE Jr, Hu WT, Lee FE, Sanz I. Woodruff MC, et al. Among authors: chen w. Nat Immunol. 2020 Dec;21(12):1506-1516. doi: 10.1038/s41590-020-00814-z. Epub 2020 Oct 7. Nat Immunol. 2020. PMID: 33028979 Free PMC article.
Poor immunogenicity upon SARS-CoV-2 mRNA vaccinations in autoimmune SLE patients is associated with pronounced EF-mediated responses and anti-BAFF/Belimumab treatment.
Faliti CE, Anam FA, Cheedarla N, Woodruff MC, Usman SY, Runnstrom MC, Van TTP, Kyu S, Ahmed H, Morrison-Porter A, Quehl H, Haddad NS, Chen W, Cheedarla S, Neish AS, Roback JD, Antia R, Khosroshahi A, Lee FE, Sanz I. Faliti CE, et al. Among authors: chen w. medRxiv [Preprint]. 2023 Jun 12:2023.06.08.23291159. doi: 10.1101/2023.06.08.23291159. medRxiv. 2023. PMID: 37398319 Free PMC article. Preprint.
Dominant extrafollicular B cell responses in severe COVID-19 disease correlate with robust viral-specific antibody production but poor clinical outcomes.
Woodruff M, Ramonell R, Cashman K, Nguyen D, Saini A, Haddad N, Ley A, Kyu S, Howell JC, Ozturk T, Lee S, Chen W, Estrada J, Morrison-Porter A, Derrico A, Anam F, Sharma M, Wu H, Le S, Jenks S, Tipton CM, Hu W, Lee FE, Sanz I. Woodruff M, et al. Among authors: chen w. medRxiv [Preprint]. 2020 Jun 22:2020.04.29.20083717. doi: 10.1101/2020.04.29.20083717. medRxiv. 2020. PMID: 32511635 Free PMC article. Updated. Preprint.
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