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BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or menin inhibitor.
Fiskus W, Piel J, Collins M, Hentemann M, Cuglievan B, Mill CP, Birdwell CE, Das K, Davis JA, Hou H, Jain A, Malovannaya A, Kadia TM, Daver N, Sasaki K, Takahashi K, Hammond D, Reville PK, Wang J, Loghavi S, Sen R, Ruan X, Su X, Flores LB, DiNardo CD, Bhalla KN. Fiskus W, et al. Among authors: takahashi k. Blood. 2024 May 16;143(20):2059-2072. doi: 10.1182/blood.2023022832. Blood. 2024. PMID: 38437498
Characteristics, clinical outcome, and prognostic significance of IDH mutations in AML.
DiNardo CD, Ravandi F, Agresta S, Konopleva M, Takahashi K, Kadia T, Routbort M, Patel KP, Mark Brandt, Pierce S, Garcia-Manero G, Cortes J, Kantarjian H. DiNardo CD, et al. Among authors: takahashi k. Am J Hematol. 2015 Aug;90(8):732-6. doi: 10.1002/ajh.24072. Am J Hematol. 2015. PMID: 26016821 Free PMC article.
IDH1 and IDH2 mutations in myelodysplastic syndromes and role in disease progression.
DiNardo CD, Jabbour E, Ravandi F, Takahashi K, Daver N, Routbort M, Patel KP, Brandt M, Pierce S, Kantarjian H, Garcia-Manero G. DiNardo CD, et al. Among authors: takahashi k. Leukemia. 2016 Apr;30(4):980-4. doi: 10.1038/leu.2015.211. Epub 2015 Jul 31. Leukemia. 2016. PMID: 26228814 Free PMC article. No abstract available.
Detectable FLT3-ITD or RAS mutation at the time of transformation from MDS to AML predicts for very poor outcomes.
Badar T, Patel KP, Thompson PA, DiNardo C, Takahashi K, Cabrero M, Borthakur G, Cortes J, Konopleva M, Kadia T, Bohannan Z, Pierce S, Jabbour EJ, Ravandi F, Daver N, Luthra R, Kantarjian H, Garcia-Manero G. Badar T, et al. Among authors: takahashi k. Leuk Res. 2015 Dec;39(12):1367-74. doi: 10.1016/j.leukres.2015.10.005. Epub 2015 Oct 19. Leuk Res. 2015. PMID: 26547258 Free PMC article.
Clofarabine Plus Low-Dose Cytarabine Is as Effective as and Less Toxic Than Intensive Chemotherapy in Elderly AML Patients.
Takahashi K, Kantarjian H, Garcia-Manero G, Borthakur G, Kadia T, DiNardo C, Jabbour E, Pierce S, Estrov Z, Konopleva M, Andreeff M, Ravandi F, Cortes J. Takahashi K, et al. Clin Lymphoma Myeloma Leuk. 2016 Mar;16(3):163-8.e1-2. doi: 10.1016/j.clml.2015.11.016. Epub 2015 Nov 24. Clin Lymphoma Myeloma Leuk. 2016. PMID: 26752456 Free PMC article.
Acute promyelocytic leukemia presented as a relapse of acute myeloid leukemia.
Vitale C, Jabbour E, Lu X, Yabe M, Kanagal Shamanna R, Daver N, Pemmaraju N, Bueso-Ramos CE, Takahashi K. Vitale C, et al. Among authors: takahashi k. Am J Hematol. 2016 Jun;91(4):E274-6. doi: 10.1002/ajh.24302. Epub 2016 Feb 29. Am J Hematol. 2016. PMID: 26798971 Free article. No abstract available.
Frontline therapy with high-dose imatinib versus second generation tyrosine kinase inhibitor in patients with chronic-phase chronic myeloid leukemia - a propensity score analysis.
Sasaki K, Kantarjian H, Jabbour E, Ravandi F, Takahashi K, Konopleva M, Borthakur G, Garcia-Manero G, Wierda W, Daver N, Jain P, Satta T, Pierce S, Rios MB, Cortes JE. Sasaki K, et al. Among authors: takahashi k. Haematologica. 2016 Aug;101(8):e324-7. doi: 10.3324/haematol.2015.139089. Epub 2016 May 12. Haematologica. 2016. PMID: 27175025 Free PMC article. No abstract available.
Evaluation of Patients and Families With Concern for Predispositions to Hematologic Malignancies Within the Hereditary Hematologic Malignancy Clinic (HHMC).
DiNardo CD, Bannon SA, Routbort M, Franklin A, Mork M, Armanios M, Mace EM, Orange JS, Jeff-Eke M, Churpek JE, Takahashi K, Jorgensen JL, Garcia-Manero G, Kornblau S, Bertuch A, Cheung H, Bhalla K, Futreal A, Godley LA, Patel KP. DiNardo CD, et al. Among authors: takahashi k. Clin Lymphoma Myeloma Leuk. 2016 Jul;16(7):417-428.e2. doi: 10.1016/j.clml.2016.04.001. Epub 2016 Apr 27. Clin Lymphoma Myeloma Leuk. 2016. PMID: 27210295 Free PMC article.
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