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Lipid nanoparticle structure and delivery route during pregnancy dictate mRNA potency, immunogenicity, and maternal and fetal outcomes.
Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2307810121. doi: 10.1073/pnas.2307810121. Epub 2024 Mar 4.
Proc Natl Acad Sci U S A. 2024.
PMID: 38437545
Free PMC article.
The strawberry-derived permeation enhancer pelargonidin enables oral protein delivery.
Lamson NG, Fein KC, Gleeson JP, Newby AN, Xian S, Cochran K, Chaudhary N, Melamed JR, Ball RL, Suri K, Ahuja V, Zhang A, Berger A, Kolodieznyi D, Schmidt BF, Silva GL, Whitehead KA.
Lamson NG, et al. Among authors: newby an.
Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2207829119. doi: 10.1073/pnas.2207829119. Epub 2022 Aug 9.
Proc Natl Acad Sci U S A. 2022.
PMID: 35943988
Free PMC article.
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Placental drug transport and fetal exposure during pregnancy is determined by drug molecular size, chemistry, and conformation.
Fein KC, Arral ML, Kim JS, Newby AN, Whitehead KA.
Fein KC, et al. Among authors: newby an.
J Control Release. 2023 Sep;361:29-39. doi: 10.1016/j.jconrel.2023.07.029. Epub 2023 Jul 31.
J Control Release. 2023.
PMID: 37473809
Free PMC article.
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Non-Viral RNA Delivery During Pregnancy: Opportunities and Challenges.
Chaudhary N, Newby AN, Whitehead KA.
Chaudhary N, et al. Among authors: newby an.
Small. 2023 Dec 25:e2306134. doi: 10.1002/smll.202306134. Online ahead of print.
Small. 2023.
PMID: 38145340
Review.
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The enhanced intestinal permeability of infant mice enables oral protein and macromolecular absorption without delivery technology.
Gleeson JP, Fein KC, Chaudhary N, Doerfler R, Newby AN, Whitehead KA.
Gleeson JP, et al. Among authors: newby an.
Int J Pharm. 2021 Jan 25;593:120120. doi: 10.1016/j.ijpharm.2020.120120. Epub 2020 Nov 26.
Int J Pharm. 2021.
PMID: 33249250
Free PMC article.
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Characterization and comparison of human and mouse milk cells.
Doerfler R, Yerneni S, Newby A, Chaudhary N, Shu A, Fein K, Hofstatter Azambuja J, Whitehead KA.
Doerfler R, et al.
PLoS One. 2024 Jan 31;19(1):e0297821. doi: 10.1371/journal.pone.0297821. eCollection 2024.
PLoS One. 2024.
PMID: 38295101
Free PMC article.
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Intestinal permeation enhancers enable oral delivery of macromolecules up to 70 kDa in size.
Fein KC, Gleeson JP, Newby AN, Whitehead KA.
Fein KC, et al. Among authors: newby an.
Eur J Pharm Biopharm. 2022 Jan;170:70-76. doi: 10.1016/j.ejpb.2021.11.010. Epub 2021 Dec 5.
Eur J Pharm Biopharm. 2022.
PMID: 34879228
Free article.
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