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Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria.
Foss S, Sakya SA, Aguinagalde L, Lustig M, Shaughnessy J, Cruz AR, Scheepmaker L, Mathiesen L, Ruso-Julve F, Anthi AK, Gjølberg TT, Mester S, Bern M, Evers M, Bratlie DB, Michaelsen TE, Schlothauer T, Sok D, Bhattacharya J, Leusen J, Valerius T, Ram S, Rooijakkers SHM, Sandlie I, Andersen JT. Foss S, et al. Among authors: cruz ar. Nat Commun. 2024 Mar 7;15(1):2007. doi: 10.1038/s41467-024-46321-9. Nat Commun. 2024. PMID: 38453922 Free PMC article.
Toward Understanding How Staphylococcal Protein A Inhibits IgG-Mediated Phagocytosis.
Cruz AR, Bentlage AEH, Blonk R, de Haas CJC, Aerts PC, Scheepmaker LM, Bouwmeester IG, Lux A, van Strijp JAG, Nimmerjahn F, van Kessel KPM, Vidarsson G, Rooijakkers SHM. Cruz AR, et al. J Immunol. 2022 Sep 15;209(6):1146-1155. doi: 10.4049/jimmunol.2200080. Epub 2022 Aug 24. J Immunol. 2022. PMID: 36002230
Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation.
Cruz AR, Boer MAD, Strasser J, Zwarthoff SA, Beurskens FJ, de Haas CJC, Aerts PC, Wang G, de Jong RN, Bagnoli F, van Strijp JAG, van Kessel KPM, Schuurman J, Preiner J, Heck AJR, Rooijakkers SHM. Cruz AR, et al. Proc Natl Acad Sci U S A. 2021 Feb 16;118(7):e2016772118. doi: 10.1073/pnas.2016772118. Proc Natl Acad Sci U S A. 2021. PMID: 33563762 Free PMC article.
112 results