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Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria.
Foss S, Sakya SA, Aguinagalde L, Lustig M, Shaughnessy J, Cruz AR, Scheepmaker L, Mathiesen L, Ruso-Julve F, Anthi AK, Gjølberg TT, Mester S, Bern M, Evers M, Bratlie DB, Michaelsen TE, Schlothauer T, Sok D, Bhattacharya J, Leusen J, Valerius T, Ram S, Rooijakkers SHM, Sandlie I, Andersen JT. Foss S, et al. Among authors: rooijakkers shm. Nat Commun. 2024 Mar 7;15(1):2007. doi: 10.1038/s41467-024-46321-9. Nat Commun. 2024. PMID: 38453922 Free PMC article.
Bacterial complement escape.
Jongerius I, Ram S, Rooijakkers S. Jongerius I, et al. Adv Exp Med Biol. 2009;666:32-48. doi: 10.1007/978-1-4419-1601-3_3. Adv Exp Med Biol. 2009. PMID: 20054973 Review.
Toward Understanding How Staphylococcal Protein A Inhibits IgG-Mediated Phagocytosis.
Cruz AR, Bentlage AEH, Blonk R, de Haas CJC, Aerts PC, Scheepmaker LM, Bouwmeester IG, Lux A, van Strijp JAG, Nimmerjahn F, van Kessel KPM, Vidarsson G, Rooijakkers SHM. Cruz AR, et al. Among authors: rooijakkers shm. J Immunol. 2022 Sep 15;209(6):1146-1155. doi: 10.4049/jimmunol.2200080. Epub 2022 Aug 24. J Immunol. 2022. PMID: 36002230
Monoclonal antibodies effectively potentiate complement activation and phagocytosis of Staphylococcus epidermidis in neonatal human plasma.
de Vor L, Beudeker CR, Flier A, Scheepmaker LM, Aerts PC, Vijlbrief DC, Bekker MN, Beurskens FJ, van Kessel KPM, de Haas CJC, Rooijakkers SHM, van der Flier M. de Vor L, et al. Among authors: rooijakkers shm. Front Immunol. 2022 Jul 29;13:933251. doi: 10.3389/fimmu.2022.933251. eCollection 2022. Front Immunol. 2022. PMID: 35967335 Free PMC article.
Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation.
Cruz AR, Boer MAD, Strasser J, Zwarthoff SA, Beurskens FJ, de Haas CJC, Aerts PC, Wang G, de Jong RN, Bagnoli F, van Strijp JAG, van Kessel KPM, Schuurman J, Preiner J, Heck AJR, Rooijakkers SHM. Cruz AR, et al. Among authors: rooijakkers shm. Proc Natl Acad Sci U S A. 2021 Feb 16;118(7):e2016772118. doi: 10.1073/pnas.2016772118. Proc Natl Acad Sci U S A. 2021. PMID: 33563762 Free PMC article.
Bacteria under stress by complement and coagulation.
Berends ET, Kuipers A, Ravesloot MM, Urbanus RT, Rooijakkers SH. Berends ET, et al. FEMS Microbiol Rev. 2014 Nov;38(6):1146-71. doi: 10.1111/1574-6976.12080. Epub 2014 Sep 3. FEMS Microbiol Rev. 2014. PMID: 25065463 Free article. Review.
98 results