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Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria.
Foss S, Sakya SA, Aguinagalde L, Lustig M, Shaughnessy J, Cruz AR, Scheepmaker L, Mathiesen L, Ruso-Julve F, Anthi AK, Gjølberg TT, Mester S, Bern M, Evers M, Bratlie DB, Michaelsen TE, Schlothauer T, Sok D, Bhattacharya J, Leusen J, Valerius T, Ram S, Rooijakkers SHM, Sandlie I, Andersen JT. Foss S, et al. Among authors: scheepmaker l. Nat Commun. 2024 Mar 7;15(1):2007. doi: 10.1038/s41467-024-46321-9. Nat Commun. 2024. PMID: 38453922 Free PMC article.
Toward Understanding How Staphylococcal Protein A Inhibits IgG-Mediated Phagocytosis.
Cruz AR, Bentlage AEH, Blonk R, de Haas CJC, Aerts PC, Scheepmaker LM, Bouwmeester IG, Lux A, van Strijp JAG, Nimmerjahn F, van Kessel KPM, Vidarsson G, Rooijakkers SHM. Cruz AR, et al. Among authors: scheepmaker lm. J Immunol. 2022 Sep 15;209(6):1146-1155. doi: 10.4049/jimmunol.2200080. Epub 2022 Aug 24. J Immunol. 2022. PMID: 36002230
Monoclonal antibodies effectively potentiate complement activation and phagocytosis of Staphylococcus epidermidis in neonatal human plasma.
de Vor L, Beudeker CR, Flier A, Scheepmaker LM, Aerts PC, Vijlbrief DC, Bekker MN, Beurskens FJ, van Kessel KPM, de Haas CJC, Rooijakkers SHM, van der Flier M. de Vor L, et al. Among authors: scheepmaker lm. Front Immunol. 2022 Jul 29;13:933251. doi: 10.3389/fimmu.2022.933251. eCollection 2022. Front Immunol. 2022. PMID: 35967335 Free PMC article.
Host-Receptor Post-Translational Modifications Refine Staphylococcal Leukocidin Cytotoxicity.
Tromp AT, Van Gent M, Jansen JP, Scheepmaker LM, Velthuizen A, De Haas CJC, Van Kessel KPM, Bardoel BW, Boettcher M, McManus MT, Van Strijp JAG, Lebbink RJ, Haas PA, Spaan AN. Tromp AT, et al. Among authors: scheepmaker lm. Toxins (Basel). 2020 Feb 6;12(2):106. doi: 10.3390/toxins12020106. Toxins (Basel). 2020. PMID: 32041354 Free PMC article.