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CDK-independent role of D-type cyclins in regulating DNA mismatch repair.
Rona G, Miwatani-Minter B, Zhang Q, Goldberg HV, Kerzhnerman MA, Howard JB, Simoneschi D, Lane E, Hobbs JW, Sassani E, Wang AA, Keegan S, Laverty DJ, Piett CG, Pongor LS, Xu ML, Andrade J, Thomas A, Sicinski P, Askenazi M, Ueberheide B, Fenyö D, Nagel ZD, Pagano M. Rona G, et al. Among authors: simoneschi d. Mol Cell. 2024 Apr 4;84(7):1224-1242.e13. doi: 10.1016/j.molcel.2024.02.010. Epub 2024 Mar 7. Mol Cell. 2024. PMID: 38458201 Free article.
D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability.
Rona G, Miwatani-Minter B, Zhang Q, Goldberg HV, Kerzhnerman MA, Howard JB, Simoneschi D, Lane E, Hobbs JW, Sassani E, Wang AA, Keegan S, Laverty DJ, Piett CG, Pongor LS, Xu ML, Andrade J, Thomas A, Sicinski P, Askenazi M, Ueberheide B, Fenyö D, Nagel ZD, Pagano M. Rona G, et al. Among authors: simoneschi d. bioRxiv [Preprint]. 2024 Jan 13:2024.01.12.575420. doi: 10.1101/2024.01.12.575420. bioRxiv. 2024. PMID: 38260436 Free PMC article. Updated. Preprint.
Uncovering the degrader of D-type cyclins.
Simoneschi D. Simoneschi D. Science. 2022 Nov 25;378(6622):845. doi: 10.1126/science.adf4868. Epub 2022 Nov 24. Science. 2022. PMID: 36423267 Free article.
CRL4AMBRA1 is a master regulator of D-type cyclins.
Simoneschi D, Rona G, Zhou N, Jeong YT, Jiang S, Milletti G, Arbini AA, O'Sullivan A, Wang AA, Nithikasem S, Keegan S, Siu Y, Cianfanelli V, Maiani E, Nazio F, Cecconi F, Boccalatte F, Fenyö D, Jones DR, Busino L, Pagano M. Simoneschi D, et al. Nature. 2021 Apr;592(7856):789-793. doi: 10.1038/s41586-021-03445-y. Epub 2021 Apr 14. Nature. 2021. PMID: 33854235 Free PMC article.
AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity.
Maiani E, Milletti G, Nazio F, Holdgaard SG, Bartkova J, Rizza S, Cianfanelli V, Lorente M, Simoneschi D, Di Marco M, D'Acunzo P, Di Leo L, Rasmussen R, Montagna C, Raciti M, De Stefanis C, Gabicagogeascoa E, Rona G, Salvador N, Pupo E, Merchut-Maya JM, Daniel CJ, Carinci M, Cesarini V, O'sullivan A, Jeong YT, Bordi M, Russo F, Campello S, Gallo A, Filomeni G, Lanzetti L, Sears RC, Hamerlik P, Bartolazzi A, Hynds RE, Pearce DR, Swanton C, Pagano M, Velasco G, Papaleo E, De Zio D, Maya-Mendoza A, Locatelli F, Bartek J, Cecconi F. Maiani E, et al. Among authors: simoneschi d. Nature. 2021 Apr;592(7856):799-803. doi: 10.1038/s41586-021-03422-5. Epub 2021 Apr 14. Nature. 2021. PMID: 33854232 Free PMC article.
Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis.
Moro L, Simoneschi D, Kurz E, Arbini AA, Jang S, Guaragnella N, Giannattasio S, Wang W, Chen YA, Pires G, Dang A, Hernandez E, Kapur P, Mishra A, Tsirigos A, Miller G, Hsieh JT, Pagano M. Moro L, et al. Among authors: simoneschi d. Nat Cell Biol. 2020 Sep;22(9):1130-1142. doi: 10.1038/s41556-020-0560-6. Epub 2020 Aug 24. Nat Cell Biol. 2020. PMID: 32839549 Free PMC article.
PHOTACs enable optical control of protein degradation.
Reynders M, Matsuura BS, Bérouti M, Simoneschi D, Marzio A, Pagano M, Trauner D. Reynders M, et al. Among authors: simoneschi d. Sci Adv. 2020 Feb 21;6(8):eaay5064. doi: 10.1126/sciadv.aay5064. eCollection 2020 Feb. Sci Adv. 2020. PMID: 32128406 Free PMC article.
15 results