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Re-education of myeloid immune cells to reduce regulatory T cell expansion and impede breast cancer progression.
Gamage HEV, Shahoei SH, Albright ST, Wang Y, Smith AJ, Farmer R, Fink EC, Jacquin E, Weisser E, Bautista RO, Henn MA, Schane CP, Nelczyk AT, Ma L, Gupta AD, Bendre SV, Nguyen T, Tiwari S, Krawczynska N, He S, Tjoanda E, Chen H, Sverdlov M, Gann PH, Boidot R, Vegran F, Fanning SW, Apetoh L, Hergenrother PJ, Nelson ER. Gamage HEV, et al. Among authors: hergenrother pj. bioRxiv [Preprint]. 2023 Aug 14:2023.08.14.553229. doi: 10.1101/2023.08.14.553229. bioRxiv. 2023. PMID: 37645737 Free PMC article. Preprint.
A Gram-negative-selective antibiotic that spares the gut microbiome.
Muñoz KA, Ulrich RJ, Vasan AK, Sinclair M, Wen PC, Holmes JR, Lee HY, Hung CC, Fields CJ, Tajkhorshid E, Lau GW, Hergenrother PJ. Muñoz KA, et al. Among authors: hergenrother pj. Nature. 2024 May 29. doi: 10.1038/s41586-024-07502-0. Online ahead of print. Nature. 2024. PMID: 38811738
Correction to "A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain".
Anmangandla A, Jana S, Peng K, Wallace SD, Bagde SR, Drown BS, Xu J, Hergenrother PJ, Fromme JC, Lin H. Anmangandla A, et al. Among authors: hergenrother pj. ACS Chem Biol. 2024 Apr 19;19(4):1023-1024. doi: 10.1021/acschembio.4c00159. Epub 2024 Mar 26. ACS Chem Biol. 2024. PMID: 38532633 Free PMC article. No abstract available.
Augmented Concentration of Isopentyl-Deoxynyboquinone in Tumors Selectively Kills NAD(P)H Quinone Oxidoreductase 1-Positive Cancer Cells through Programmed Necrotic and Apoptotic Mechanisms.
Wang J, Su X, Jiang L, Boudreau MW, Chatkewitz LE, Kilgore JA, Zahid KR, Williams NS, Chen Y, Liu S, Hergenrother PJ, Huang X. Wang J, et al. Among authors: hergenrother pj. Cancers (Basel). 2023 Dec 14;15(24):5844. doi: 10.3390/cancers15245844. Cancers (Basel). 2023. PMID: 38136388 Free PMC article.
Discovery of KRB-456, a KRAS G12D Switch-I/II Allosteric Pocket Binder That Inhibits the Growth of Pancreatic Cancer Patient-derived Tumors.
Kazi A, Ranjan A, Kumar M V V, Agianian B, Garcia Chavez M, Vudatha V, Wang R, Vangipurapu R, Chen L, Kennedy P, Subramanian K, Quirke JCK, Beato F, Underwood PW, Fleming JB, Trevino J, Hergenrother PJ, Gavathiotis E, Sebti SM. Kazi A, et al. Among authors: hergenrother pj. Cancer Res Commun. 2023 Dec 28;3(12):2623-2639. doi: 10.1158/2767-9764.CRC-23-0222. Cancer Res Commun. 2023. PMID: 38051103 Free PMC article.
Porin-independent accumulation in Pseudomonas enables antibiotic discovery.
Geddes EJ, Gugger MK, Garcia A, Chavez MG, Lee MR, Perlmutter SJ, Bieniossek C, Guasch L, Hergenrother PJ. Geddes EJ, et al. Among authors: hergenrother pj. Nature. 2023 Dec;624(7990):145-153. doi: 10.1038/s41586-023-06760-8. Epub 2023 Nov 22. Nature. 2023. PMID: 37993720
184 results