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A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models.
Ren F, Aliper A, Chen J, Zhao H, Rao S, Kuppe C, Ozerov IV, Zhang M, Witte K, Kruse C, Aladinskiy V, Ivanenkov Y, Polykovskiy D, Fu Y, Babin E, Qiao J, Liang X, Mou Z, Wang H, Pun FW, Ayuso PT, Veviorskiy A, Song D, Liu S, Zhang B, Naumov V, Ding X, Kukharenko A, Izumchenko E, Zhavoronkov A. Ren F, et al. Among authors: zhavoronkov a. Nat Biotechnol. 2024 Mar 8. doi: 10.1038/s41587-024-02143-0. Online ahead of print. Nat Biotechnol. 2024. PMID: 38459338
Common pathway signature in lung and liver fibrosis.
Makarev E, Izumchenko E, Aihara F, Wysocki PT, Zhu Q, Buzdin A, Sidransky D, Zhavoronkov A, Atala A. Makarev E, et al. Among authors: zhavoronkov a. Cell Cycle. 2016 Jul 2;15(13):1667-73. doi: 10.1080/15384101.2016.1152435. Epub 2016 Jun 7. Cell Cycle. 2016. PMID: 27267766 Free PMC article.
In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development.
Ozerov IV, Lezhnina KV, Izumchenko E, Artemov AV, Medintsev S, Vanhaelen Q, Aliper A, Vijg J, Osipov AN, Labat I, West MD, Buzdin A, Cantor CR, Nikolsky Y, Borisov N, Irincheeva I, Khokhlovich E, Sidransky D, Camargo ML, Zhavoronkov A. Ozerov IV, et al. Among authors: zhavoronkov a. Nat Commun. 2016 Nov 16;7:13427. doi: 10.1038/ncomms13427. Nat Commun. 2016. PMID: 27848968 Free PMC article.
Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy.
Ravi R, Noonan KA, Pham V, Bedi R, Zhavoronkov A, Ozerov IV, Makarev E, V Artemov A, Wysocki PT, Mehra R, Nimmagadda S, Marchionni L, Sidransky D, Borrello IM, Izumchenko E, Bedi A. Ravi R, et al. Among authors: zhavoronkov a. Nat Commun. 2018 Feb 21;9(1):741. doi: 10.1038/s41467-017-02696-6. Nat Commun. 2018. PMID: 29467463 Free PMC article.
Adversarial Threshold Neural Computer for Molecular de Novo Design.
Putin E, Asadulaev A, Vanhaelen Q, Ivanenkov Y, Aladinskaya AV, Aliper A, Zhavoronkov A. Putin E, et al. Among authors: zhavoronkov a. Mol Pharm. 2018 Oct 1;15(10):4386-4397. doi: 10.1021/acs.molpharmaceut.7b01137. Epub 2018 Mar 30. Mol Pharm. 2018. PMID: 29569445 Free article.
Reinforced Adversarial Neural Computer for de Novo Molecular Design.
Putin E, Asadulaev A, Ivanenkov Y, Aladinskiy V, Sanchez-Lengeling B, Aspuru-Guzik A, Zhavoronkov A. Putin E, et al. Among authors: zhavoronkov a. J Chem Inf Model. 2018 Jun 25;58(6):1194-1204. doi: 10.1021/acs.jcim.7b00690. Epub 2018 Jun 12. J Chem Inf Model. 2018. PMID: 29762023 Free article.
258 results