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Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening.
Shishodia S, Nuñez R, Strohmier BP, Bursch KL, Goetz CJ, Olp MD, Jensen DR, Fenske TG, Ordonez-Rubiano SC, Blau ME, Roach MK, Peterson FC, Volkman BF, Dykhuizen EC, Smith BC. Shishodia S, et al. Among authors: nunez r. J Med Chem. 2022 Oct 27;65(20):13714-13735. doi: 10.1021/acs.jmedchem.2c00864. Epub 2022 Oct 13. J Med Chem. 2022. PMID: 36227159 Free PMC article.
Fragment-based screening by protein-detected NMR spectroscopy.
Kerber PJ, Nuñez R, Jensen DR, Zhou AL, Peterson FC, Hill RB, Volkman BF, Smith BC. Kerber PJ, et al. Among authors: nunez r. Methods Enzymol. 2023;690:285-310. doi: 10.1016/bs.mie.2023.06.018. Epub 2023 Jul 29. Methods Enzymol. 2023. PMID: 37858532
Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types.
Jones Lipinski RA, Stancill JS, Nuñez R, Wynia-Smith SL, Sprague DJ, Nord JA, Bird A, Corbett JA, Smith BC. Jones Lipinski RA, et al. Among authors: nunez r. Am J Physiol Regul Integr Comp Physiol. 2024 Jun 1;326(6):R515-R527. doi: 10.1152/ajpregu.00259.2023. Epub 2024 Apr 15. Am J Physiol Regul Integr Comp Physiol. 2024. PMID: 38618911
Combining loop with thiazide diuretics in patients discharged home after a heart failure decompensation: Association with 30-day outcomes.
Miró Ò, Núñez J, Trullàs JC, Lopez-Ayala P, Llauger L, Alquézar-Arbé A, Miñana G, Mollar A, de la Espriella R, Lorenzo M, Jacob J, Espinosa B, Garcés-Horna V, Aguirre A, Fortuny MJ, Martínez-Nadal G, Gil V, Mueller C, Llorens P; ICA-SEMES; INCLIVA; ALCALOTIC research groups. Miró Ò, et al. Eur J Intern Med. 2024 May 18:S0953-6205(24)00213-9. doi: 10.1016/j.ejim.2024.05.009. Online ahead of print. Eur J Intern Med. 2024. PMID: 38763846
Group 2 innate lymphoid cells are key in lipid transfer protein allergy pathogenesis.
Palomares F, Pérez-Sánchez N, Nieto N, Núñez R, Cañas JA, Martín-Astorga MDC, Cruz-Amaya A, Torres MJ, Eguíluz-Gracia I, Mayorga C, Gómez F. Palomares F, et al. Among authors: nunez r. Front Immunol. 2024 Apr 25;15:1385101. doi: 10.3389/fimmu.2024.1385101. eCollection 2024. Front Immunol. 2024. PMID: 38725998 Free PMC article.
The significance of metabolic alkalosis on acute decompensated heart failure: the ALCALOTIC study.
Trullàs JC, Peláez AI, Blázquez J, Sánchez-Biosca A, López-Reborio ML, Salamanca-Bautista P, Fernández-Rodríguez JM, Vázquez-Ronda MÁ, Dávila-Ramos MF, Mendoza-Ruiz-De-Zuazu H, Morales-Rull JL, Olmedo-Llanes J, Llàcer P, Conde-Martel A; ALCALOTIC study investigators. Trullàs JC, et al. Clin Res Cardiol. 2024 May 6. doi: 10.1007/s00392-024-02452-z. Online ahead of print. Clin Res Cardiol. 2024. PMID: 38709335
528 results