Olp MD - Search Results

1

Cancer-associated polybromo-1 bromodomain 4 missense variants variably impact bromodomain ligand binding and cell growth suppression.

Bursch KL, Goetz CJ, Jiao G, Nuñez R, Olp MD, Dhiman A, Khurana M, Zimmermann MT, Urrutia RA, Dykhuizen EC, Smith BC. Bursch KL, et al. Among authors: olp md. J Biol Chem. 2024 Apr;300(4):107146. doi: 10.1016/j.jbc.2024.107146. Epub 2024 Mar 7. J Biol Chem. 2024. PMID: 38460939 Free PMC article.

2

Analysis of continuous enzyme kinetic data using ICEKAT.

Bursch KL, Olp MD, Smith BC. Bursch KL, et al. Among authors: olp md. Methods Enzymol. 2023;690:109-129. doi: 10.1016/bs.mie.2023.06.019. Epub 2023 Jul 29. Methods Enzymol. 2023. PMID: 37858527

3

Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening.

Shishodia S, Nuñez R, Strohmier BP, Bursch KL, Goetz CJ, Olp MD, Jensen DR, Fenske TG, Ordonez-Rubiano SC, Blau ME, Roach MK, Peterson FC, Volkman BF, Dykhuizen EC, Smith BC. Shishodia S, et al. Among authors: olp md. J Med Chem. 2022 Oct 27;65(20):13714-13735. doi: 10.1021/acs.jmedchem.2c00864. Epub 2022 Oct 13. J Med Chem. 2022. PMID: 36227159 Free PMC article.

4

Chemical Regulation of the Protein Quality Control E3 Ubiquitin Ligase C-Terminus of Hsc70 Interacting Protein (CHIP).

Kanack AJ, Olp MD, Newsom OJ, Scaglione JB, Gooden DM, McMahon K, Smith BC, Scaglione KM. Kanack AJ, et al. Among authors: olp md. Chembiochem. 2022 Mar 18;23(6):e202100633. doi: 10.1002/cbic.202100633. Epub 2022 Feb 3. Chembiochem. 2022. PMID: 35061295 Free PMC article.

5

ICEKAT: an interactive online tool for calculating initial rates from continuous enzyme kinetic traces.

Olp MD, Kalous KS, Smith BC. Olp MD, et al. BMC Bioinformatics. 2020 May 14;21(1):186. doi: 10.1186/s12859-020-3513-y. BMC Bioinformatics. 2020. PMID: 32410570 Free PMC article.

6

Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites.

Olp MD, Sprague DJ, Goetz CJ, Kathman SG, Wynia-Smith SL, Shishodia S, Summers SB, Xu Z, Statsyuk AV, Smith BC. Olp MD, et al. ACS Chem Biol. 2020 Apr 17;15(4):1036-1049. doi: 10.1021/acschembio.0c00058. Epub 2020 Mar 23. ACS Chem Biol. 2020. PMID: 32149490 Free PMC article.

7

Non-sedating benzodiazepines cause paralysis and tissue damage in the parasitic blood fluke Schistosoma mansoni.

McCusker P, Mian MY, Li G, Olp MD, Tiruveedhula VVNPB, Rashid F, Golani LK, Verma RS, Smith BC, Cook JM, Chan JD. McCusker P, et al. Among authors: olp md. PLoS Negl Trop Dis. 2019 Nov 15;13(11):e0007826. doi: 10.1371/journal.pntd.0007826. eCollection 2019 Nov. PLoS Negl Trop Dis. 2019. PMID: 31730614 Free PMC article.

8

Development and Validation of 2D Difference Intensity Analysis for Chemical Library Screening by Protein-Detected NMR Spectroscopy.

Egner JM, Jensen DR, Olp MD, Kennedy NW, Volkman BF, Peterson FC, Smith BC, Hill RB. Egner JM, et al. Among authors: olp md. Chembiochem. 2018 Mar 2;19(5):448-458. doi: 10.1002/cbic.201700386. Epub 2018 Jan 25. Chembiochem. 2018. PMID: 29239081 Free PMC article.

9

Metabolically Derived Lysine Acylations and Neighboring Modifications Tune the Binding of the BET Bromodomains to Histone H4.

Olp MD, Zhu N, Smith BC. Olp MD, et al. Biochemistry. 2017 Oct 17;56(41):5485-5495. doi: 10.1021/acs.biochem.7b00595. Epub 2017 Oct 5. Biochemistry. 2017. PMID: 28945351 Free PMC article.

10

Mechanism of Sirt1 NAD+-dependent Protein Deacetylase Inhibition by Cysteine S-Nitrosation.

Kalous KS, Wynia-Smith SL, Olp MD, Smith BC. Kalous KS, et al. Among authors: olp md. J Biol Chem. 2016 Dec 2;291(49):25398-25410. doi: 10.1074/jbc.M116.754655. Epub 2016 Oct 18. J Biol Chem. 2016. PMID: 27756843 Free PMC article.

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