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Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules.
Hickey CM, Digianantonio KM, Zimmermann K, Harbin A, Quinn C, Patel A, Gareiss P, Chapman A, Tiberi B, Dobrodziej J, Corradi J, Cacace AM, Langley DR, Békés M. Hickey CM, et al. Among authors: langley dr. Nat Struct Mol Biol. 2024 Feb;31(2):311-322. doi: 10.1038/s41594-023-01146-w. Epub 2024 Jan 4. Nat Struct Mol Biol. 2024. PMID: 38177675
Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients.
Rouet R, Henry JY, Johansen MD, Sobti M, Balachandran H, Langley DB, Walker GJ, Lenthall H, Jackson J, Ubiparipovic S, Mazigi O, Schofield P, Burnett DL, Brown SHJ, Martinello M, Hudson B, Gilroy N, Post JJ, Kelleher A, Jäck HM, Goodnow CC, Turville SG, Rawlinson WD, Bull RA, Stewart AG, Hansbro PM, Christ D. Rouet R, et al. Among authors: langley db. Nat Commun. 2023 Feb 8;14(1):687. doi: 10.1038/s41467-023-36295-5. Nat Commun. 2023. PMID: 36755042 Free PMC article.
Genetic and structural basis of the human anti-α-galactosyl antibody response.
Langley DB, Schofield P, Nevoltris D, Jackson J, Jackson KJL, Peters TJ, Burk M, Matthews JM, Basten A, Goodnow CC, van Nunen S, Reed JH, Christ D. Langley DB, et al. Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2123212119. doi: 10.1073/pnas.2123212119. Epub 2022 Jul 8. Proc Natl Acad Sci U S A. 2022. PMID: 35867757 Free PMC article.
218 results