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Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1.
Pirie E, Ray S, Pan C, Fu W, Powers AF, Polikoff D, Miller CM, Kudrna KM, Harris EN, Lusis AJ, Crooke RM, Lee RG. Pirie E, et al. Among authors: pan c. PLoS Genet. 2018 Oct 29;14(10):e1007732. doi: 10.1371/journal.pgen.1007732. eCollection 2018 Oct. PLoS Genet. 2018. PMID: 30372444 Free PMC article.
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2.
Chella Krishnan K, Vergnes L, Acín-Pérez R, Stiles L, Shum M, Ma L, Mouisel E, Pan C, Moore TM, Péterfy M, Romanoski CE, Reue K, Björkegren JLM, Laakso M, Liesa M, Lusis AJ. Chella Krishnan K, et al. Among authors: pan c. Nat Metab. 2021 Nov;3(11):1552-1568. doi: 10.1038/s42255-021-00481-w. Epub 2021 Oct 25. Nat Metab. 2021. PMID: 34697471 Free PMC article.
Placental genomics mediates genetic associations with complex health traits and disease.
Bhattacharya A, Freedman AN, Avula V, Harris R, Liu W, Pan C, Lusis AJ, Joseph RM, Smeester L, Hartwell HJ, Kuban KCK, Marsit CJ, Li Y, O'Shea TM, Fry RC, Santos HP Jr. Bhattacharya A, et al. Among authors: pan c. Nat Commun. 2022 Feb 4;13(1):706. doi: 10.1038/s41467-022-28365-x. Nat Commun. 2022. PMID: 35121757 Free PMC article.
Sex differences in heart mitochondria regulate diastolic dysfunction.
Cao Y, Vergnes L, Wang YC, Pan C, Chella Krishnan K, Moore TM, Rosa-Garrido M, Kimball TH, Zhou Z, Charugundla S, Rau CD, Seldin MM, Wang J, Wang Y, Vondriska TM, Reue K, Lusis AJ. Cao Y, et al. Among authors: pan c. Nat Commun. 2022 Jul 4;13(1):3850. doi: 10.1038/s41467-022-31544-5. Nat Commun. 2022. PMID: 35787630 Free PMC article.
Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD.
Park SH, Helsley RN, Fadhul T, Willoughby JLS, Noetzli L, Tu HC, Solheim MH, Fujisaka S, Pan H, Dreyfuss JM, Bons J, Rose J, King CD, Schilling B, Lusis AJ, Pan C, Gupta M, Kulkarni RN, Fitzgerald K, Kern PA, Divanovic S, Kahn CR, Softic S. Park SH, et al. Among authors: pan c, pan h. bioRxiv [Preprint]. 2023 Jan 27:2023.01.27.525605. doi: 10.1101/2023.01.27.525605. bioRxiv. 2023. PMID: 36747758 Free PMC article. Updated. Preprint.
Conserved multi-tissue transcriptomic adaptations to exercise training in humans and mice.
Moore TM, Lee S, Olsen T, Morselli M, Strumwasser AR, Lin AJ, Zhou Z, Abrishami A, Garcia SM, Bribiesca J, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Nguyen CQA, Anand ATS, Yackly A, Mendoza LQ, Leyva BK, Aliman C, Artiga DJ, Meng Y, Charugundla S, Pan C, Jedian V, Seldin MM, Ahn IS, Diamante G, Blencowe M, Yang X, Mouisel E, Pellegrini M, Turcotte LP, Birkeland KI, Norheim F, Drevon CA, Lusis AJ, Hevener AL. Moore TM, et al. Among authors: pan c. Cell Rep. 2023 May 30;42(5):112499. doi: 10.1016/j.celrep.2023.112499. Epub 2023 May 12. Cell Rep. 2023. PMID: 37178122 Free article.
Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy.
Chella Krishnan K, El Hachem EJ, Keller MP, Patel SG, Carroll L, Vegas AD, Gerdes Gyuricza I, Light C, Cao Y, Pan C, Kaczor-Urbanowicz KE, Shravah V, Anum D, Pellegrini M, Lee CF, Seldin MM, Rosenthal NA, Churchill GA, Attie AD, Parker B, James DE, Lusis AJ. Chella Krishnan K, et al. Among authors: pan c. Elife. 2023 Jun 5;12:e82619. doi: 10.7554/eLife.82619. Elife. 2023. PMID: 37276142 Free PMC article.
7,824 results