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Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3C-like Protease.
Dampalla CS, Rathnayake AD, Galasiti Kankanamalage AC, Kim Y, Perera KD, Nguyen HN, Miller MJ, Madden TK, Picard HR, Thurman HA, Kashipathy MM, Liu L, Battaile KP, Lovell S, Chang KO, Groutas WC. Dampalla CS, et al. Among authors: groutas wc. J Med Chem. 2022 Jun 9;65(11):7818-7832. doi: 10.1021/acs.jmedchem.2c00224. Epub 2022 May 31. J Med Chem. 2022. PMID: 35638577 Free PMC article.
Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease.
Tiew KC, He G, Aravapalli S, Mandadapu SR, Gunnam MR, Alliston KR, Lushington GH, Kim Y, Chang KO, Groutas WC. Tiew KC, et al. Among authors: groutas wc. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5315-9. doi: 10.1016/j.bmcl.2011.07.016. Epub 2011 Jul 14. Bioorg Med Chem Lett. 2011. PMID: 21802286 Free PMC article.
Structural and inhibitor studies of norovirus 3C-like proteases.
Takahashi D, Kim Y, Lovell S, Prakash O, Groutas WC, Chang KO. Takahashi D, et al. Among authors: groutas wc. Virus Res. 2013 Dec 26;178(2):437-44. doi: 10.1016/j.virusres.2013.09.008. Epub 2013 Sep 17. Virus Res. 2013. PMID: 24055466 Free PMC article.
Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors.
Prior AM, Kim Y, Weerasekara S, Moroze M, Alliston KR, Uy RA, Groutas WC, Chang KO, Hua DH. Prior AM, et al. Among authors: groutas wc. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6317-20. doi: 10.1016/j.bmcl.2013.09.070. Epub 2013 Sep 30. Bioorg Med Chem Lett. 2013. PMID: 24125888 Free PMC article.
Structure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. Structure-activity relationships and biochemical, X-ray crystallographic, cell-based, and in vivo studies.
Galasiti Kankanamalage AC, Kim Y, Weerawarna PM, Uy RA, Damalanka VC, Mandadapu SR, Alliston KR, Mehzabeen N, Battaile KP, Lovell S, Chang KO, Groutas WC. Galasiti Kankanamalage AC, et al. Among authors: groutas wc. J Med Chem. 2015 Apr 9;58(7):3144-55. doi: 10.1021/jm5019934. Epub 2015 Mar 19. J Med Chem. 2015. PMID: 25761614 Free PMC article.
112 results