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The prostaglandin E2 EP3 receptor has disparate effects on islet insulin secretion and content in β-cells in a high-fat diet-induced mouse model of obesity.
Neuman JC, Reuter A, Carbajal KA, Schaid MD, Kelly G, Connors K, Kaiser C, Krause J, Hurley LD, Olvera A, Davis DB, Wisinski JA, Gannon M, Kimple ME. Neuman JC, et al. Am J Physiol Endocrinol Metab. 2024 May 1;326(5):E567-E576. doi: 10.1152/ajpendo.00061.2023. Epub 2024 Mar 13. Am J Physiol Endocrinol Metab. 2024. PMID: 38477664
Agonist-independent Gαz activity negatively regulates beta-cell compensation in a diet-induced obesity model of type 2 diabetes.
Schaid MD, Green CL, Peter DC, Gallagher SJ, Guthery E, Carbajal KA, Harrington JM, Kelly GM, Reuter A, Wehner ML, Brill AL, Neuman JC, Lamming DW, Kimple ME. Schaid MD, et al. Among authors: neuman jc. J Biol Chem. 2021 Jan-Jun;296:100056. doi: 10.1074/jbc.RA120.015585. Epub 2020 Nov 24. J Biol Chem. 2021. PMID: 33172888 Free PMC article.
Systemic Metabolic Alterations Correlate with Islet-Level Prostaglandin E2 Production and Signaling Mechanisms That Predict β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes.
Schaid MD, Zhu Y, Richardson NE, Patibandla C, Ong IM, Fenske RJ, Neuman JC, Guthery E, Reuter A, Sandhu HK, Fuller MH, Cox ED, Davis DB, Layden BT, Brasier AR, Lamming DW, Ge Y, Kimple ME. Schaid MD, et al. Among authors: neuman jc. Metabolites. 2021 Jan 16;11(1):58. doi: 10.3390/metabo11010058. Metabolites. 2021. PMID: 33467110 Free PMC article.
Rat prostaglandin EP3 receptor is highly promiscuous and is the sole prostanoid receptor family member that regulates INS-1 (832/3) cell glucose-stimulated insulin secretion.
Sandhu HK, Neuman JC, Schaid MD, Davis SE, Connors KM, Challa R, Guthery E, Fenske RJ, Patibandla C, Breyer RM, Kimple ME. Sandhu HK, et al. Among authors: neuman jc. Pharmacol Res Perspect. 2021 Apr;9(2):e00736. doi: 10.1002/prp2.736. Pharmacol Res Perspect. 2021. PMID: 33694300 Free PMC article.
27 results