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Mitochondrial complex I activity in microglia sustains neuroinflammation.
Peruzzotti-Jametti L, Willis CM, Krzak G, Hamel R, Pirvan L, Ionescu RB, Reisz JA, Prag HA, Garcia-Segura ME, Wu V, Xiang Y, Barlas B, Casey AM, van den Bosch AMR, Nicaise AM, Roth L, Bates GR, Huang H, Prasad P, Vincent AE, Frezza C, Viscomi C, Balmus G, Takats Z, Marioni JC, D'Alessandro A, Murphy MP, Mohorianu I, Pluchino S. Peruzzotti-Jametti L, et al. Among authors: viscomi c. Nature. 2024 Apr;628(8006):195-203. doi: 10.1038/s41586-024-07167-9. Epub 2024 Mar 13. Nature. 2024. PMID: 38480879 Free PMC article.
Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo.
Gammage PA, Viscomi C, Simard ML, Costa ASH, Gaude E, Powell CA, Van Haute L, McCann BJ, Rebelo-Guiomar P, Cerutti R, Zhang L, Rebar EJ, Zeviani M, Frezza C, Stewart JB, Minczuk M. Gammage PA, et al. Among authors: viscomi c. Nat Med. 2018 Nov;24(11):1691-1695. doi: 10.1038/s41591-018-0165-9. Epub 2018 Sep 24. Nat Med. 2018. PMID: 30250142 Free PMC article.
Niche stiffness underlies the ageing of central nervous system progenitor cells.
Segel M, Neumann B, Hill MFE, Weber IP, Viscomi C, Zhao C, Young A, Agley CC, Thompson AJ, Gonzalez GA, Sharma A, Holmqvist S, Rowitch DH, Franze K, Franklin RJM, Chalut KJ. Segel M, et al. Among authors: viscomi c. Nature. 2019 Sep;573(7772):130-134. doi: 10.1038/s41586-019-1484-9. Epub 2019 Aug 15. Nature. 2019. PMID: 31413369 Free PMC article.
Structural basis for a complex I mutation that blocks pathological ROS production.
Yin Z, Burger N, Kula-Alwar D, Aksentijević D, Bridges HR, Prag HA, Grba DN, Viscomi C, James AM, Mottahedin A, Krieg T, Murphy MP, Hirst J. Yin Z, et al. Among authors: viscomi c. Nat Commun. 2021 Jan 29;12(1):707. doi: 10.1038/s41467-021-20942-w. Nat Commun. 2021. PMID: 33514727 Free PMC article.
Neural stem cells traffic functional mitochondria via extracellular vesicles.
Peruzzotti-Jametti L, Bernstock JD, Willis CM, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Krzak G, Kittel Á, Benincá C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Peacock B, Muller KH, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S. Peruzzotti-Jametti L, et al. Among authors: viscomi c. PLoS Biol. 2021 Apr 7;19(4):e3001166. doi: 10.1371/journal.pbio.3001166. eCollection 2021 Apr. PLoS Biol. 2021. PMID: 33826607 Free PMC article.
APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS.
Signes A, Cerutti R, Dickson AS, Benincá C, Hinchy EC, Ghezzi D, Carrozzo R, Bertini E, Murphy MP, Nathan JA, Viscomi C, Fernandez-Vizarra E, Zeviani M. Signes A, et al. Among authors: viscomi c. EMBO Mol Med. 2019 Jan;11(1):e9582. doi: 10.15252/emmm.201809582. EMBO Mol Med. 2019. PMID: 30552096 Free PMC article.
152 results