Hilpert K - Search Results

1

Discovery and Characterization of a New Class of C5aR1 Antagonists Showing In Vivo Activity.

Hubler F, Renneberg D, Siendt H, Stamm S, Hilpert K, Caroff E, Delahaye S, Froidevaux S, Murphy MJ. Hubler F, et al. Among authors: hilpert k. J Med Chem. 2024 Mar 14;67(5):4100-4119. doi: 10.1021/acs.jmedchem.3c02375. Epub 2024 Mar 4. J Med Chem. 2024. PMID: 38482828

2

4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel.

Caroff E, Hubler F, Meyer E, Renneberg D, Gnerre C, Treiber A, Rey M, Hess P, Steiner B, Hilpert K, Riederer MA. Caroff E, et al. Among authors: hilpert k. J Med Chem. 2015 Dec 10;58(23):9133-53. doi: 10.1021/acs.jmedchem.5b00933. Epub 2015 Nov 18. J Med Chem. 2015. PMID: 26550844

3

Optimization of 2-phenyl-pyrimidine-4-carboxamides towards potent, orally bioavailable and selective P2Y(12) antagonists for inhibition of platelet aggregation.

Caroff E, Meyer E, Treiber A, Hilpert K, Riederer MA. Caroff E, et al. Among authors: hilpert k. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4323-31. doi: 10.1016/j.bmcl.2014.06.070. Epub 2014 Jul 1. Bioorg Med Chem Lett. 2014. PMID: 25113932

4

Discovery of novel bridged tetrahydronaphthalene derivatives as potent T/L-type calcium channel blockers.

Renneberg D, Hubler F, Rey M, Hess P, Delahaye S, Gatfield J, Iglarz M, Hilpert K. Renneberg D, et al. Among authors: hilpert k. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3941-6. doi: 10.1016/j.bmcl.2015.07.038. Epub 2015 Jul 21. Bioorg Med Chem Lett. 2015. PMID: 26231163

5

Identification of 2-(2-(1-naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acid (setipiprant/ACT-129968), a potent, selective, and orally bioavailable chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonist.

Fretz H, Valdenaire A, Pothier J, Hilpert K, Gnerre C, Peter O, Leroy X, Riederer MA. Fretz H, et al. Among authors: hilpert k. J Med Chem. 2013 Jun 27;56(12):4899-911. doi: 10.1021/jm400122f. Epub 2013 Jun 13. J Med Chem. 2013. PMID: 23721423

6

Discovery and optimization of 4,5-diarylisoxazoles as potent dual inhibitors of pyruvate dehydrogenase kinase and heat shock protein 90.

Meng T, Zhang D, Xie Z, Yu T, Wu S, Wyder L, Regenass U, Hilpert K, Huang M, Geng M, Shen J. Meng T, et al. Among authors: hilpert k. J Med Chem. 2014 Dec 11;57(23):9832-43. doi: 10.1021/jm5010144. Epub 2014 Nov 26. J Med Chem. 2014. PMID: 25383915

7

Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity.

Groebke Zbinden K, Banner DW, Hilpert K, Himber J, Lavé T, Riederer MA, Stahl M, Tschopp TB, Obst-Sander U. Groebke Zbinden K, et al. Among authors: hilpert k. Bioorg Med Chem. 2006 Aug 1;14(15):5357-69. doi: 10.1016/j.bmc.2006.03.042. Epub 2006 Apr 18. Bioorg Med Chem. 2006. PMID: 16621574

8

Design and synthesis of potent and highly selective thrombin inhibitors.

Hilpert K, Ackermann J, Banner DW, Gast A, Gubernator K, Hadváry P, Labler L, Müller K, Schmid G, Tschopp TB, et al. Hilpert K, et al. J Med Chem. 1994 Nov 11;37(23):3889-901. doi: 10.1021/jm00049a008. J Med Chem. 1994. PMID: 7966150

9

Correction to "Discovery and Optimization of 4,5-Diarylisoxazoles as Potent Dual Inhibitors of Pyruvate Dehydrogenase Kinase and Heat Shock Protein 90".

Meng T, Zhang D, Xie Z, Yu T, Wu S, Wyder L, Regenass U, Hilpert K, Huang M, Geng M, Shen J. Meng T, et al. Among authors: hilpert k. J Med Chem. 2019 Dec 12;62(23):10926. doi: 10.1021/acs.jmedchem.9b01878. Epub 2019 Nov 26. J Med Chem. 2019. PMID: 31769671 No abstract available.

10

Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors.

Zbinden KG, Obst-Sander U, Hilpert K, Kühne H, Banner DW, Böhm HJ, Stahl M, Ackermann J, Alig L, Weber L, Wessel HP, Riederer MA, Tschopp TB, Lavé T. Zbinden KG, et al. Among authors: hilpert k. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5344-52. doi: 10.1016/j.bmcl.2005.04.079. Epub 2005 Oct 4. Bioorg Med Chem Lett. 2005. PMID: 16213138

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