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Targeting Mycobacterium tuberculosis Persistence through Inhibition of the Trehalose Catalytic Shift.
ACS Infect Dis. 2024 Apr 12;10(4):1391-1404. doi: 10.1021/acsinfecdis.4c00138. Epub 2024 Mar 14.
ACS Infect Dis. 2024.
PMID: 38485491
Free PMC article.
Chemoenzymatic Synthesis of Trehalosamine, an Aminoglycoside Antibiotic and Precursor to Mycobacterial Imaging Probes.
Groenevelt JM, Meints LM, Stothard AI, Poston AW, Fiolek TJ, Finocchietti DH, Mulholand VM, Woodruff PJ, Swarts BM.
Groenevelt JM, et al. Among authors: stothard ai.
J Org Chem. 2018 Aug 3;83(15):8662-8667. doi: 10.1021/acs.joc.8b00810. Epub 2018 Jul 23.
J Org Chem. 2018.
PMID: 29973045
Free PMC article.
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Degradation-resistant trehalose analogues block utilization of trehalose by hypervirulent Clostridioides difficile.
Danielson ND , Collins J , Stothard AI , Dong QQ , Kalera K , Woodruff PJ , DeBosch BJ , Britton RA , Swarts BM .
Danielson ND , et al. Among authors: stothard ai.
Chem Commun (Camb). 2019 Apr 23;55(34):5009-5012. doi: 10.1039/c9cc01300h.
Chem Commun (Camb). 2019.
PMID: 30968891
Free PMC article.
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The role of chemoenzymatic synthesis in advancing trehalose analogues as tools for combatting bacterial pathogens.
Kalera K, Stothard AI, Woodruff PJ, Swarts BM.
Kalera K, et al. Among authors: stothard ai.
Chem Commun (Camb). 2020 Oct 1;56(78):11528-11547. doi: 10.1039/d0cc04955g.
Chem Commun (Camb). 2020.
PMID: 32914793
Free PMC article.
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Validamycin A Delays Development and Prevents Flight in Aedes aegypti (Diptera: Culicidae).
Marten AD, Stothard AI, Kalera K, Swarts BM, Conway MJ.
Marten AD, et al. Among authors: stothard ai.
J Med Entomol. 2020 Jul 4;57(4):1096-1103. doi: 10.1093/jme/tjaa004.
J Med Entomol. 2020.
PMID: 31982917
Free PMC article.
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Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPARγ.
Higgins CB, Zhang Y, Mayer AL, Fujiwara H, Stothard AI, Graham MJ, Swarts BM, DeBosch BJ.
Higgins CB, et al. Among authors: stothard ai.
JCI Insight. 2018 Aug 23;3(16):e120794. doi: 10.1172/jci.insight.120794. eCollection 2018 Aug 23.
JCI Insight. 2018.
PMID: 30135298
Free PMC article.
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Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting.
Zhang Y, Higgins CB, Fortune HM, Chen P, Stothard AI, Mayer AL, Swarts BM, DeBosch BJ.
Zhang Y, et al. Among authors: stothard ai.
Nat Commun. 2019 Apr 8;10(1):1587. doi: 10.1038/s41467-019-09642-8.
Nat Commun. 2019.
PMID: 30962478
Free PMC article.
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Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice.
Zhang Y, Shaikh N, Ferey JL, Wankhade UD, Chintapalli SV, Higgins CB, Crowley JR, Heitmeier MR, Stothard AI, Mihi B, Good M, Higashiyama T, Swarts BM, Hruz PW, Shankar K, Tarr PI, DeBosch BJ.
Zhang Y, et al. Among authors: stothard ai.
Gastroenterology. 2020 Apr;158(5):1402-1416.e2. doi: 10.1053/j.gastro.2019.11.295. Epub 2019 Dec 12.
Gastroenterology. 2020.
PMID: 31838076
Free PMC article.
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