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First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure.
Zwirner S, Abu Rmilah AA, Klotz S, Pfaffenroth B, Kloevekorn P, Moschopoulou AA, Schuette S, Haag M, Selig R, Li K, Zhou W, Nelson E, Poso A, Chen H, Amiot B, Jia Y, Minshew A, Michalak G, Cui W, Rist E, Longerich T, Jung B, Felgendreff P, Trompak O, Premsrirut PK, Gries K, Muerdter TE, Heinkele G, Wuestefeld T, Shapiro D, Weissbach M, Koenigsrainer A, Sipos B, Ab E, Zacarias MO, Theisgen S, Gruenheit N, Biskup S, Schwab M, Albrecht W, Laufer S, Nyberg S, Zender L. Zwirner S, et al. Among authors: laufer s. Cell. 2024 Mar 28;187(7):1666-1684.e26. doi: 10.1016/j.cell.2024.02.023. Epub 2024 Mar 14. Cell. 2024. PMID: 38490194 Free PMC article. Clinical Trial.
HDAC specificity and kinase off-targeting by purine-benzohydroxamate anti-hematological tumor agents.
Waitman KB, de Almeida LC, Primi MC, Carlos JAEG, Ruiz C, Kronenberger T, Laufer S, Goettert MI, Poso A, Vassiliades SV, de Souza VAM, Toledo MFZJ, Hassimotto NMA, Cameron MD, Bannister TD, Costa-Lotufo LV, Machado-Neto JA, Tavares MT, Parise-Filho R. Waitman KB, et al. Among authors: laufer s. Eur J Med Chem. 2024 Jan 5;263:115935. doi: 10.1016/j.ejmech.2023.115935. Epub 2023 Nov 10. Eur J Med Chem. 2024. PMID: 37989057
Targeting Lewy body dementia with neflamapimod-rasagiline hybrids.
Albertini C, Petralla S, Massenzio F, Monti B, Rizzardi N, Bergamini C, Uliassi E, Borges F, Chavarria D, Fricker G, Goettert M, Kronenberger T, Gehringer M, Laufer S, Bolognesi ML. Albertini C, et al. Among authors: laufer s. Arch Pharm (Weinheim). 2024 Feb 27:e2300525. doi: 10.1002/ardp.202300525. Online ahead of print. Arch Pharm (Weinheim). 2024. PMID: 38412454
Generation of a patient-specific hiPS cell line with heterozygous GNB2 mutation (UKMi003-A) causative for human sinus node dysfunction and a corresponding CRISPR/Cas9-corrected isogenic control (UKMi004-A).
Kayser A, Dittmann S, Hamidi J, Laufer SD, Krampe R, Mearini G, Hansen A, Schulze-Bahr E. Kayser A, et al. Among authors: laufer sd. Stem Cell Res. 2024 May 18;78:103446. doi: 10.1016/j.scr.2024.103446. Online ahead of print. Stem Cell Res. 2024. PMID: 38776645
531 results