Chazin WJ - Search Results

1

A mechanistic model of primer synthesis from catalytic structures of DNA polymerase α-primase.

Mullins EA, Salay LE, Durie CL, Bradley NP, Jackman JE, Ohi MD, Chazin WJ, Eichman BF. Mullins EA, et al. Among authors: chazin wj. Nat Struct Mol Biol. 2024 May;31(5):777-790. doi: 10.1038/s41594-024-01227-4. Epub 2024 Mar 15. Nat Struct Mol Biol. 2024. PMID: 38491139

2

Insights into eukaryotic primer synthesis from structures of the p48 subunit of human DNA primase.

Vaithiyalingam S, Arnett DR, Aggarwal A, Eichman BF, Fanning E, Chazin WJ. Vaithiyalingam S, et al. Among authors: chazin wj. J Mol Biol. 2014 Feb 6;426(3):558-69. doi: 10.1016/j.jmb.2013.11.007. Epub 2013 Nov 13. J Mol Biol. 2014. PMID: 24239947 Free PMC article.

3

A Polymerase With Potential: The Fe-S Cluster in Human DNA Primase.

Holt ME, Salay LE, Chazin WJ. Holt ME, et al. Among authors: chazin wj. Methods Enzymol. 2017;595:361-390. doi: 10.1016/bs.mie.2017.07.002. Epub 2017 Aug 18. Methods Enzymol. 2017. PMID: 28882207

4

Structural insights into the U-box, a domain associated with multi-ubiquitination.

Ohi MD, Vander Kooi CW, Rosenberg JA, Chazin WJ, Gould KL. Ohi MD, et al. Among authors: chazin wj. Nat Struct Biol. 2003 Apr;10(4):250-5. doi: 10.1038/nsb906. Nat Struct Biol. 2003. PMID: 12627222 Free PMC article.

5

Physical interactions between Mcm10, DNA, and DNA polymerase alpha.

Warren EM, Huang H, Fanning E, Chazin WJ, Eichman BF. Warren EM, et al. Among authors: chazin wj. J Biol Chem. 2009 Sep 4;284(36):24662-72. doi: 10.1074/jbc.M109.020438. Epub 2009 Jul 16. J Biol Chem. 2009. PMID: 19608746 Free PMC article.

6

Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase.

Vaithiyalingam S, Warren EM, Eichman BF, Chazin WJ. Vaithiyalingam S, et al. Among authors: chazin wj. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13684-9. doi: 10.1073/pnas.1002009107. Epub 2010 Jul 19. Proc Natl Acad Sci U S A. 2010. PMID: 20643958 Free PMC article.

7

The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport.

O'Brien E, Holt ME, Thompson MK, Salay LE, Ehlinger AC, Chazin WJ, Barton JK. O'Brien E, et al. Among authors: chazin wj. Science. 2017 Feb 24;355(6327):eaag1789. doi: 10.1126/science.aag1789. Science. 2017. PMID: 28232525 Free PMC article.

8

Substrate Binding Regulates Redox Signaling in Human DNA Primase.

O'Brien E, Holt ME, Salay LE, Chazin WJ, Barton JK. O'Brien E, et al. Among authors: chazin wj. J Am Chem Soc. 2018 Dec 12;140(49):17153-17162. doi: 10.1021/jacs.8b09914. Epub 2018 Nov 29. J Am Chem Soc. 2018. PMID: 30433774 Free PMC article.

9

Functional and structural similarity of human DNA primase [4Fe4S] cluster domain constructs.

Holt ME, Salay LE, O'Brien E, Barton JK, Chazin WJ. Holt ME, et al. Among authors: chazin wj. PLoS One. 2018 Dec 18;13(12):e0209345. doi: 10.1371/journal.pone.0209345. eCollection 2018. PLoS One. 2018. PMID: 30562384 Free PMC article.

10

Modification of the 4Fe-4S Cluster Charge Transport Pathway Alters RNA Synthesis by Yeast DNA Primase.

Salay LE, Blee AM, Raza MK, Gallagher KS, Chen H, Dorfeuille AJ, Barton JK, Chazin WJ. Salay LE, et al. Among authors: chazin wj. Biochemistry. 2022 Jun 7;61(11):1113-1123. doi: 10.1021/acs.biochem.2c00100. Epub 2022 May 26. Biochemistry. 2022. PMID: 35617695 Free PMC article.

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