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Unveiling the Antiviral Capabilities of Targeting Human Dihydroorotate Dehydrogenase against SARS-CoV-2.
Purificação AD, Silva-Mendonça S, Cruz LV, Sacramento CQ, Temerozo JR, Fintelman-Rodrigues N, de Freitas CS, Godoi BF, Vaidergorn MM, Leite JA, Salazar Alvarez LC, Freitas MV, Silvac MFB, Martin BA, Lopez RFV, Neves BJ, Costa FTM, Souza TML, da Silva Emery F, Andrade CH, Nonato MC. Purificação AD, et al. Among authors: sacramento cq. ACS Omega. 2024 Feb 28;9(10):11418-11430. doi: 10.1021/acsomega.3c07845. eCollection 2024 Mar 12. ACS Omega. 2024. PMID: 38496952 Free PMC article.
Computational and Experimental Approaches Identify Beta-Blockers as Potential SARS-CoV-2 Spike Inhibitors.
Puhl AC, Mottin M, Sacramento CQ, Tavella TA, Dias GG, Fintelman-Rodrigues N, Temerozo JR, Dias SSG, Ramos PRPDS, Merten EM, Pearce KH, Costa FTM, Premkumar L, Souza TML, Andrade CH, Ekins S. Puhl AC, et al. Among authors: sacramento cq. ACS Omega. 2022 Aug 8;7(32):27950-27958. doi: 10.1021/acsomega.2c01707. eCollection 2022 Aug 16. ACS Omega. 2022. PMID: 35983371 Free PMC article.
Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV-2 and Potential Mechanisms.
Puhl AC, Fritch EJ, Lane TR, Tse LV, Yount BL, Sacramento CQ, Fintelman-Rodrigues N, Tavella TA, Maranhão Costa FT, Weston S, Logue J, Frieman M, Premkumar L, Pearce KH, Hurst BL, Andrade CH, Levi JA, Johnson NJ, Kisthardt SC, Scholle F, Souza TML, Moorman NJ, Baric RS, Madrid PB, Ekins S. Puhl AC, et al. Among authors: sacramento cq. ACS Omega. 2021 Mar 10;6(11):7454-7468. doi: 10.1021/acsomega.0c05996. eCollection 2021 Mar 23. ACS Omega. 2021. PMID: 33778258 Free PMC article.
Agathisflavone, a natural biflavonoid that inhibits SARS-CoV-2 replication by targeting its proteases.
Chaves OA, Lima CR, Fintelman-Rodrigues N, Sacramento CQ, de Freitas CS, Vazquez L, Temerozo JR, Rocha MEN, Dias SSG, Carels N, Bozza PT, Castro-Faria-Neto HC, Souza TML. Chaves OA, et al. Among authors: sacramento cq. Int J Biol Macromol. 2022 Dec 1;222(Pt A):1015-1026. doi: 10.1016/j.ijbiomac.2022.09.204. Epub 2022 Sep 29. Int J Biol Macromol. 2022. PMID: 36183752 Free PMC article.
Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics.
Wang X, Sacramento CQ, Jockusch S, Chaves OA, Tao C, Fintelman-Rodrigues N, Chien M, Temerozo JR, Li X, Kumar S, Xie W, Patel DJ, Meyer C, Garzia A, Tuschl T, Bozza PT, Russo JJ, Souza TML, Ju J. Wang X, et al. Among authors: sacramento cq. bioRxiv [Preprint]. 2021 Jul 21:2021.07.21.453274. doi: 10.1101/2021.07.21.453274. bioRxiv. 2021. PMID: 34312622 Free PMC article. Updated. Preprint.
SARS-CoV-2 Proteins Bind to Hemoglobin and Its Metabolites.
Lechuga GC, Souza-Silva F, Sacramento CQ, Trugilho MRO, Valente RH, Napoleão-Pêgo P, Dias SSG, Fintelman-Rodrigues N, Temerozo JR, Carels N, Alves CR, Pereira MCS, Provance DW Jr, Souza TML, De-Simone SG. Lechuga GC, et al. Among authors: sacramento cq. Int J Mol Sci. 2021 Aug 21;22(16):9035. doi: 10.3390/ijms22169035. Int J Mol Sci. 2021. PMID: 34445741 Free PMC article.
WIN 55,212-2 shows anti-inflammatory and survival properties in human iPSC-derived cardiomyocytes infected with SARS-CoV-2.
Aragão LGHS, Oliveira JT, Temerozo JR, Mendes MA, Salerno JA, Pedrosa CSG, Puig-Pijuan T, Veríssimo CP, Ornelas IM, Torquato T, Vitória G, Sacramento CQ, Fintelman-Rodrigues N, da Silva Gomes Dias S, Cardoso Soares V, Souza LRQ, Karmirian K, Goto-Silva L, Biagi D, Cruvinel EM, Dariolli R, Furtado DR, Bozza PT, Borges HL, Souza TML, Guimarães MZP, Rehen SK. Aragão LGHS, et al. Among authors: sacramento cq. PeerJ. 2021 Oct 8;9:e12262. doi: 10.7717/peerj.12262. eCollection 2021. PeerJ. 2021. PMID: 34707939 Free PMC article.
Inhibition of SARS-CoV-2 infection in human iPSC-derived cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoarchitecture and beating.
Salerno JA, Torquato T, Temerozo JR, Goto-Silva L, Karmirian K, Mendes MA, Sacramento CQ, Fintelman-Rodrigues N, Souza LRQ, Ornelas IM, Veríssimo CP, Aragão LGHS, Vitória G, Pedrosa CSG, da Silva Gomes Dias S, Cardoso Soares V, Puig-Pijuan T, Salazar V, Dariolli R, Biagi D, Furtado DR, Barreto Chiarini L, Borges HL, Bozza PT, Zaluar P Guimarães M, Souza TML, Rehen SK. Salerno JA, et al. Among authors: sacramento cq. PeerJ. 2021 Dec 20;9:e12595. doi: 10.7717/peerj.12595. eCollection 2021. PeerJ. 2021. PMID: 35036128 Free PMC article.
Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture.
Wang X, Sacramento CQ, Jockusch S, Chaves OA, Tao C, Fintelman-Rodrigues N, Chien M, Temerozo JR, Li X, Kumar S, Xie W, Patel DJ, Meyer C, Garzia A, Tuschl T, Bozza PT, Russo JJ, Souza TML, Ju J. Wang X, et al. Among authors: sacramento cq. Commun Biol. 2022 Feb 22;5(1):154. doi: 10.1038/s42003-022-03101-9. Commun Biol. 2022. PMID: 35194144 Free PMC article.
48 results