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Page 1
Design of amyloidogenic peptide traps.
Sahtoe DD, Andrzejewska EA, Han HL, Rennella E, Schneider MM, Meisl G, Ahlrichs M, Decarreau J, Nguyen H, Kang A, Levine P, Lamb M, Li X, Bera AK, Kay LE, Knowles TPJ, Baker D. Sahtoe DD, et al. Among authors: kay le. Nat Chem Biol. 2024 Mar 19. doi: 10.1038/s41589-024-01578-5. Online ahead of print. Nat Chem Biol. 2024. PMID: 38503834
Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson's disease.
Nim S, O'Hara DM, Corbi-Verge C, Perez-Riba A, Fujisawa K, Kapadia M, Chau H, Albanese F, Pawar G, De Snoo ML, Ngana SG, Kim J, El-Agnaf OMA, Rennella E, Kay LE, Kalia SK, Kalia LV, Kim PM. Nim S, et al. Among authors: kay le. Nat Commun. 2023 Apr 19;14(1):2150. doi: 10.1038/s41467-023-37464-2. Nat Commun. 2023. PMID: 37076542 Free PMC article.
Structural transitions enable interleukin-18 maturation and signaling.
Dong Y, Bonin JP, Devant P, Liang Z, Sever AIM, Mintseris J, Aramini JM, Du G, Gygi SP, Kagan JC, Kay LE, Wu H. Dong Y, et al. Among authors: kay le. Immunity. 2024 May 8:S1074-7613(24)00220-6. doi: 10.1016/j.immuni.2024.04.015. Online ahead of print. Immunity. 2024. PMID: 38733997
Activation of caspase-9 on the apoptosome as studied by methyl-TROSY NMR.
Sever AIM, Alderson TR, Rennella E, Aramini JM, Liu ZH, Harkness RW, Kay LE. Sever AIM, et al. Among authors: kay le. Proc Natl Acad Sci U S A. 2023 Dec 19;120(51):e2310944120. doi: 10.1073/pnas.2310944120. Epub 2023 Dec 12. Proc Natl Acad Sci U S A. 2023. PMID: 38085782
443 results