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Design of amyloidogenic peptide traps.
Sahtoe DD, Andrzejewska EA, Han HL, Rennella E, Schneider MM, Meisl G, Ahlrichs M, Decarreau J, Nguyen H, Kang A, Levine P, Lamb M, Li X, Bera AK, Kay LE, Knowles TPJ, Baker D. Sahtoe DD, et al. Among authors: li x. Nat Chem Biol. 2024 Mar 19. doi: 10.1038/s41589-024-01578-5. Online ahead of print. Nat Chem Biol. 2024. PMID: 38503834
Computationally designed peptide macrocycle inhibitors of New Delhi metallo-β-lactamase 1.
Mulligan VK, Workman S, Sun T, Rettie S, Li X, Worrall LJ, Craven TW, King DT, Hosseinzadeh P, Watkins AM, Renfrew PD, Guffy S, Labonte JW, Moretti R, Bonneau R, Strynadka NCJ, Baker D. Mulligan VK, et al. Among authors: li x. Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):e2012800118. doi: 10.1073/pnas.2012800118. Proc Natl Acad Sci U S A. 2021. PMID: 33723038 Free PMC article.
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites.
Hosseinzadeh P, Watson PR, Craven TW, Li X, Rettie S, Pardo-Avila F, Bera AK, Mulligan VK, Lu P, Ford AS, Weitzner BD, Stewart LJ, Moyer AP, Di Piazza M, Whalen JG, Greisen PJ, Christianson DW, Baker D. Hosseinzadeh P, et al. Among authors: li x. Nat Commun. 2021 Jun 7;12(1):3384. doi: 10.1038/s41467-021-23609-8. Nat Commun. 2021. PMID: 34099674 Free PMC article.
Generation of Potent and Stable GLP-1 Analogues Via "Serine Ligation".
Levine PM, Craven TW, Li X, Balana AT, Bird GH, Godes M, Salveson PJ, Erickson PW, Lamb M, Ahlrichs M, Murphy M, Ogohara C, Said MY, Walensky LD, Pratt MR, Baker D. Levine PM, et al. Among authors: li x. ACS Chem Biol. 2022 Apr 15;17(4):804-809. doi: 10.1021/acschembio.2c00075. Epub 2022 Mar 23. ACS Chem Biol. 2022. PMID: 35319882 Free PMC article.
Accurate de novo design of membrane-traversing macrocycles.
Bhardwaj G, O'Connor J, Rettie S, Huang YH, Ramelot TA, Mulligan VK, Alpkilic GG, Palmer J, Bera AK, Bick MJ, Di Piazza M, Li X, Hosseinzadeh P, Craven TW, Tejero R, Lauko A, Choi R, Glynn C, Dong L, Griffin R, van Voorhis WC, Rodriguez J, Stewart L, Montelione GT, Craik D, Baker D. Bhardwaj G, et al. Among authors: li x. Cell. 2022 Sep 15;185(19):3520-3532.e26. doi: 10.1016/j.cell.2022.07.019. Epub 2022 Aug 29. Cell. 2022. PMID: 36041435 Free PMC article.
De novo design of small beta barrel proteins.
Kim DE, Jensen DR, Feldman D, Tischer D, Saleem A, Chow CM, Li X, Carter L, Milles L, Nguyen H, Kang A, Bera AK, Peterson FC, Volkman BF, Ovchinnikov S, Baker D. Kim DE, et al. Among authors: li x. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2207974120. doi: 10.1073/pnas.2207974120. Epub 2023 Mar 10. Proc Natl Acad Sci U S A. 2023. PMID: 36897987 Free PMC article.
Stepwise design of pseudosymmetric protein hetero-oligomers.
Kibler RD, Lee S, Kennedy MA, Wicky BIM, Lai SM, Kostelic MM, Li X, Chow CM, Carter L, Wysocki VH, Stoddard BL, Baker D. Kibler RD, et al. Among authors: li x. bioRxiv [Preprint]. 2023 Apr 7:2023.04.07.535760. doi: 10.1101/2023.04.07.535760. bioRxiv. 2023. PMID: 37066191 Free PMC article. Preprint.
168,925 results
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