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Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome.
Lana-Elola E, Aoidi R, Llorian M, Gibbins D, Buechsenschuetz C, Bussi C, Flynn H, Gilmore T, Watson-Scales S, Haugsten Hansen M, Hayward D, Song OR, Brault V, Herault Y, Deau E, Meijer L, Snijders AP, Gutierrez MG, Fisher EMC, Tybulewicz VLJ. Lana-Elola E, et al. Among authors: bussi c. Sci Transl Med. 2024 Jan 24;16(731):eadd6883. doi: 10.1126/scitranslmed.add6883. Epub 2024 Jan 24. Sci Transl Med. 2024. PMID: 38266108 Free PMC article.
Stress granules plug and stabilize damaged endolysosomal membranes.
Bussi C, Mangiarotti A, Vanhille-Campos C, Aylan B, Pellegrino E, Athanasiadi N, Fearns A, Rodgers A, Franzmann TM, Šarić A, Dimova R, Gutierrez MG. Bussi C, et al. Nature. 2023 Nov;623(7989):1062-1069. doi: 10.1038/s41586-023-06726-w. Epub 2023 Nov 15. Nature. 2023. PMID: 37968398 Free PMC article.
Systemic sterile induced-co-expression of IL-12 and IL-18 drive IFN-γ-dependent activation of microglia and recruitment of MHC-II-expressing inflammatory monocytes into the brain.
Gaviglio EA, Peralta Ramos JM, Arroyo DS, Bussi C, Iribarren P, Rodriguez-Galan MC. Gaviglio EA, et al. Among authors: bussi c. Int Immunopharmacol. 2022 Apr;105:108546. doi: 10.1016/j.intimp.2022.108546. Epub 2022 Jan 21. Int Immunopharmacol. 2022. PMID: 35074570 Free PMC article.
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