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Thiazolyl-isatin derivatives: Synthesis, in silico studies, in vitro biological profile against breast cancer cells, mRNA expression, P-gp modulation, and interactions of Akt2 and VIM proteins.
Freitas LAB, Sousa C, Lima BS, Duarte D, Gomes PATM, Ramos CGC, Costa VCM, Pitta MGDR, Rêgo MJBM, de Simone CA, Videira M, Leite ACL. Freitas LAB, et al. Among authors: leite acl. Chem Biol Interact. 2024 May 1;394:110954. doi: 10.1016/j.cbi.2024.110954. Epub 2024 Mar 20. Chem Biol Interact. 2024. PMID: 38518852
Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice.
Moreira DR, Costa SP, Hernandes MZ, Rabello MM, de Oliveira Filho GB, de Melo CM, da Rocha LF, de Simone CA, Ferreira RS, Fradico JR, Meira CS, Guimarães ET, Srivastava RM, Pereira VR, Soares MB, Leite AC. Moreira DR, et al. J Med Chem. 2012 Dec 27;55(24):10918-36. doi: 10.1021/jm301518v. Epub 2012 Dec 7. J Med Chem. 2012. PMID: 23167554
Conformational restriction of aryl thiosemicarbazones produces potent and selective anti-Trypanosoma cruzi compounds which induce apoptotic parasite death.
Magalhaes Moreira DR, de Oliveira AD, Teixeira de Moraes Gomes PA, de Simone CA, Villela FS, Ferreira RS, da Silva AC, dos Santos TA, Brelaz de Castro MC, Pereira VR, Leite AC. Magalhaes Moreira DR, et al. Eur J Med Chem. 2014 Mar 21;75:467-78. doi: 10.1016/j.ejmech.2014.02.001. Epub 2014 Feb 3. Eur J Med Chem. 2014. PMID: 24561675
Improvement of in vivo anticancer and antiangiogenic potential of thalidomide derivatives.
da Costa PM, da Costa MP, Carvalho AA, Cavalcanti SM, de Oliveira Cardoso MV, de Oliveira Filho GB, de Araújo Viana D, Fechine-Jamacaru FV, Leite AC, de Moraes MO, Pessoa C, Ferreira PM. da Costa PM, et al. Chem Biol Interact. 2015 Sep 5;239:174-83. doi: 10.1016/j.cbi.2015.06.037. Epub 2015 Jun 29. Chem Biol Interact. 2015. PMID: 26134001 Free article.
62 results