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A High Threshold of Biotherapeutic Aggregate Numbers is Needed to Induce an Immunogenic Response In Vitro, In Vivo, and in the Clinic.
Cohen JR, Brych SR, Prabhu S, Bi V, Elbaradei A, Tokuda JM, Xiang C, Hokom M, Cui X, Ly C, Amos N, Sun J, Calamba D, Herskovitz J, Capili A, Nourbakhsh K, Merlo A, Carreon J, Wypych J, Narhi LO, Jawa V, Joubert MK. Cohen JR, et al. Among authors: herskovitz j. Pharm Res. 2024 Apr;41(4):651-672. doi: 10.1007/s11095-024-03678-2. Epub 2024 Mar 22. Pharm Res. 2024. PMID: 38519817
Use of In Vitro Assays to Assess Immunogenicity Risk of Antibody-Based Biotherapeutics.
Joubert MK, Deshpande M, Yang J, Reynolds H, Bryson C, Fogg M, Baker MP, Herskovitz J, Goletz TJ, Zhou L, Moxness M, Flynn GC, Narhi LO, Jawa V. Joubert MK, et al. Among authors: herskovitz j. PLoS One. 2016 Aug 5;11(8):e0159328. doi: 10.1371/journal.pone.0159328. eCollection 2016. PLoS One. 2016. PMID: 27494246 Free PMC article.
CD4+ effector T cells accelerate Alzheimer's disease in mice.
Machhi J, Yeapuri P, Lu Y, Foster E, Chikhale R, Herskovitz J, Namminga KL, Olson KE, Abdelmoaty MM, Gao J, Quadros RM, Kiyota T, Jingjing L, Kevadiya BD, Wang X, Liu Y, Poluektova LY, Gurumurthy CB, Mosley RL, Gendelman HE. Machhi J, et al. Among authors: herskovitz j. J Neuroinflammation. 2021 Nov 19;18(1):272. doi: 10.1186/s12974-021-02308-7. J Neuroinflammation. 2021. PMID: 34798897 Free PMC article.
CRISPR-Cas9 Mediated Exonic Disruption for HIV-1 Elimination.
Herskovitz J, Hasan M, Patel M, Blomberg WR, Cohen JD, Machhi J, Shahjin F, Mosley RL, McMillan J, Kevadiya BD, Gendelman HE. Herskovitz J, et al. EBioMedicine. 2021 Nov;73:103678. doi: 10.1016/j.ebiom.2021.103678. Epub 2021 Nov 10. EBioMedicine. 2021. PMID: 34774454 Free PMC article.
The Immunopathobiology of SARS-CoV-2 Infection.
Patel M, Shahjin F, Cohen JD, Hasan M, Machhi J, Chugh H, Singh S, Das S, Kulkarni TA, Herskovitz J, Meigs DD, Chandra R, Hettie KS, Mosley RL, Kevadiya BD, Gendelman HE. Patel M, et al. Among authors: herskovitz j. FEMS Microbiol Rev. 2021 Nov 23;45(6):fuab035. doi: 10.1093/femsre/fuab035. FEMS Microbiol Rev. 2021. PMID: 34160586 Free PMC article.
Diagnostics for SARS-CoV-2 infections.
Kevadiya BD, Machhi J, Herskovitz J, Oleynikov MD, Blomberg WR, Bajwa N, Soni D, Das S, Hasan M, Patel M, Senan AM, Gorantla S, McMillan J, Edagwa B, Eisenberg R, Gurumurthy CB, Reid SPM, Punyadeera C, Chang L, Gendelman HE. Kevadiya BD, et al. Among authors: herskovitz j. Nat Mater. 2021 May;20(5):593-605. doi: 10.1038/s41563-020-00906-z. Epub 2021 Feb 15. Nat Mater. 2021. PMID: 33589798 Free PMC article. Review.
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