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A High Threshold of Biotherapeutic Aggregate Numbers is Needed to Induce an Immunogenic Response In Vitro, In Vivo, and in the Clinic.
Cohen JR, Brych SR, Prabhu S, Bi V, Elbaradei A, Tokuda JM, Xiang C, Hokom M, Cui X, Ly C, Amos N, Sun J, Calamba D, Herskovitz J, Capili A, Nourbakhsh K, Merlo A, Carreon J, Wypych J, Narhi LO, Jawa V, Joubert MK. Cohen JR, et al. Among authors: wypych j. Pharm Res. 2024 Apr;41(4):651-672. doi: 10.1007/s11095-024-03678-2. Epub 2024 Mar 22. Pharm Res. 2024. PMID: 38519817
Classification and characterization of therapeutic antibody aggregates.
Joubert MK, Luo Q, Nashed-Samuel Y, Wypych J, Narhi LO. Joubert MK, et al. Among authors: wypych j. J Biol Chem. 2011 Jul 15;286(28):25118-33. doi: 10.1074/jbc.M110.160457. Epub 2011 Mar 25. J Biol Chem. 2011. PMID: 21454532 Free PMC article.
Chemical modifications were also identified in a separate report (Luo, Q., Joubert, M. K., Stevenson, R., Narhi, L. O., and Wypych, J. (2011) J. Biol. Chem. 286, 25134-25144). Aggregates were categorized into seven discrete classes, based on the traits descri …
Chemical modifications were also identified in a separate report (Luo, Q., Joubert, M. K., Stevenson, R., Narhi, L. O., and Wypych, …
Chemical modifications in therapeutic protein aggregates generated under different stress conditions.
Luo Q, Joubert MK, Stevenson R, Ketchem RR, Narhi LO, Wypych J. Luo Q, et al. Among authors: wypych j. J Biol Chem. 2011 Jul 15;286(28):25134-44. doi: 10.1074/jbc.M110.160440. Epub 2011 Apr 25. J Biol Chem. 2011. PMID: 21518762 Free PMC article.
In a separate study, additional biophysical characterization was performed to arrange these aggregates into a classification system (Joubert, M. K., Luo, Q., Nashed-Samuel, Y., Wypych, J., and Narhi, L. O. (2011) J. Biol. Chem. 286, 25118-25133). ...
In a separate study, additional biophysical characterization was performed to arrange these aggregates into a classification system (Joubert …
119 results