Rigby AC - Search Results

1

Discovery of HC-7366: An Orally Bioavailable and Efficacious GCN2 Kinase Activator.

Thomson CG, Aicher TD, Cheng W, Du H, Dudgeon C, Li AH, Li B, Lightcap E, Luo D, Mulvihill M, Pan P, Rahemtulla BF, Rigby AC, Sherborne B, Sood S, Surguladze D, Talbot EPA, Tameire F, Taylor S, Wang Y, Wojnarowicz P, Xiao F, Ramurthy S. Thomson CG, et al. Among authors: rigby ac. J Med Chem. 2024 Apr 11;67(7):5259-5271. doi: 10.1021/acs.jmedchem.3c02384. Epub 2024 Mar 26. J Med Chem. 2024. PMID: 38530741

2

PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors.

Stokes ME, Calvo V, Fujisawa S, Dudgeon C, Huang S, Ballal N, Shen L, Gasparek J, Betzenhauser M, Taylor SJ, Staschke KA, Rigby AC, Mulvihill MJ, Bose N, Lightcap ES, Surguladze D. Stokes ME, et al. Among authors: rigby ac. Clin Cancer Res. 2023 Dec 1;29(23):4870-4882. doi: 10.1158/1078-0432.CCR-23-1182. Clin Cancer Res. 2023. PMID: 37733811 Free PMC article.

3

Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors.

Stokes ME, Surman MD, Calvo V, Surguladze D, Li AH, Gasparek J, Betzenhauser M, Zhu G, Du H, Rigby AC, Mulvihill MJ. Stokes ME, et al. Among authors: rigby ac. Pharmaceutics. 2022 Oct 19;14(10):2233. doi: 10.3390/pharmaceutics14102233. Pharmaceutics. 2022. PMID: 36297668 Free PMC article.

4

Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors.

Calvo V, Surguladze D, Li AH, Surman MD, Malibhatla S, Bandaru M, Jonnalagadda SK, Adarasandi R, Velmala M, Singireddi DRP, Velpuri M, Nareddy BR, Sastry V, Mandati C, Guguloth R, Siddiqui S, Patil BS, Chad E, Wolfley J, Gasparek J, Feldman K, Betzenhauser M, Wiens B, Koszelak-Rosenblum M, Zhu G, Du H, Rigby AC, Mulvihill MJ. Calvo V, et al. Among authors: rigby ac. Bioorg Med Chem Lett. 2021 Jul 1;43:128058. doi: 10.1016/j.bmcl.2021.128058. Epub 2021 Apr 23. Bioorg Med Chem Lett. 2021. PMID: 33895276 Free article.

5

NMR ¹H,¹³C, ¹⁵N resonance assignment of the G12C mutant of human K-Ras bound to GppNHp.

Sharma AK, Lee SJ, Zhou M, Rigby AC, Townson SA. Sharma AK, et al. Among authors: rigby ac. Biomol NMR Assign. 2019 Apr;13(1):227-231. doi: 10.1007/s12104-019-09882-1. Epub 2019 Feb 23. Biomol NMR Assign. 2019. PMID: 30798456

6

NMR ¹H,¹³C, ¹⁵N backbone and ¹³C side chain resonance assignment of the G12C mutant of human K-Ras bound to GDP.

Sharma AK, Lee SJ, Rigby AC, Townson SA. Sharma AK, et al. Among authors: rigby ac. Biomol NMR Assign. 2018 Oct;12(2):269-272. doi: 10.1007/s12104-018-9821-8. Epub 2018 May 2. Biomol NMR Assign. 2018. PMID: 29721757 Free PMC article.

7

Human SLC26A4/Pendrin STAS domain is a nucleotide-binding protein: Refolding and characterization for structural studies.

Sharma AK, Krieger T, Rigby AC, Zelikovic I, Alper SL. Sharma AK, et al. Among authors: rigby ac. Biochem Biophys Rep. 2016 Aug 26;8:184-191. doi: 10.1016/j.bbrep.2016.08.022. eCollection 2016 Dec. Biochem Biophys Rep. 2016. PMID: 28955955 Free PMC article.

8

Identification of Novel Non-secosteroidal Vitamin D Receptor Agonists with Potent Cardioprotective Effects and devoid of Hypercalcemia.

Khedkar SA, Samad MA, Choudhury S, Lee JY, Zhang D, Thadhani RI, Karumanchi SA, Rigby AC, Kang PM. Khedkar SA, et al. Among authors: rigby ac. Sci Rep. 2017 Aug 16;7(1):8427. doi: 10.1038/s41598-017-08670-y. Sci Rep. 2017. PMID: 28814738 Free PMC article.

9

Inhibition of serum and glucocorticoid regulated kinase-1 as novel therapy for cardiac arrhythmia disorders.

Bezzerides VJ, Zhang A, Xiao L, Simonson B, Khedkar SA, Baba S, Ottaviano F, Lynch S, Hessler K, Rigby AC, Milan D, Das S, Rosenzweig A. Bezzerides VJ, et al. Among authors: rigby ac. Sci Rep. 2017 Mar 23;7(1):346. doi: 10.1038/s41598-017-00413-3. Sci Rep. 2017. PMID: 28336914 Free PMC article.

10

NMR insight into myosin-binding subunit coiled-coil structure reveals binding interface with protein kinase G-Iα leucine zipper in vascular function.

Sharma AK, Birrane G, Anklin C, Rigby AC, Alper SL. Sharma AK, et al. Among authors: rigby ac. J Biol Chem. 2017 Apr 28;292(17):7052-7065. doi: 10.1074/jbc.M117.781260. Epub 2017 Mar 9. J Biol Chem. 2017. PMID: 28280239 Free PMC article.

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