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Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds.
Zhang BC, Laursen MF, Hu L, Hazrati H, Narita R, Jensen LS, Hansen AS, Huang J, Zhang Y, Ding X, Muyesier M, Nilsson E, Banasik A, Zeiler C, Mogensen TH, Etzerodt A, Agger R, Johannsen M, Kofod-Olsen E, Paludan SR, Jakobsen MR. Zhang BC, et al. Among authors: johannsen m. Nat Commun. 2024 Mar 29;15(1):2760. doi: 10.1038/s41467-024-47046-5. Nat Commun. 2024. PMID: 38553448 Free PMC article.
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP.
Jønsson KL, Laustsen A, Krapp C, Skipper KA, Thavachelvam K, Hotter D, Egedal JH, Kjolby M, Mohammadi P, Prabakaran T, Sørensen LK, Sun C, Jensen SB, Holm CK, Lebbink RJ, Johannsen M, Nyegaard M, Mikkelsen JG, Kirchhoff F, Paludan SR, Jakobsen MR. Jønsson KL, et al. Among authors: johannsen m. Nat Commun. 2017 Feb 10;8:14391. doi: 10.1038/ncomms14391. Nat Commun. 2017. PMID: 28186168 Free PMC article.
cGAS is activated by DNA in a length-dependent manner.
Luecke S, Holleufer A, Christensen MH, Jønsson KL, Boni GA, Sørensen LK, Johannsen M, Jakobsen MR, Hartmann R, Paludan SR. Luecke S, et al. Among authors: johannsen m. EMBO Rep. 2017 Oct;18(10):1707-1715. doi: 10.15252/embr.201744017. Epub 2017 Aug 10. EMBO Rep. 2017. PMID: 28801534 Free PMC article.
The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation.
Farahani E, Reinert LS, Narita R, Serrero MC, Skouboe MK, van der Horst D, Assil S, Zhang B, Iversen MB, Gutierrez E, Hazrati H, Johannsen M, Olagnier D, Kunze R, Denham M, Mogensen TH, Lappe M, Paludan SR. Farahani E, et al. Among authors: johannsen m. Cell Rep. 2024 Feb 27;43(2):113792. doi: 10.1016/j.celrep.2024.113792. Epub 2024 Feb 15. Cell Rep. 2024. PMID: 38363679 Free PMC article.
Stimulation of the Hydroxycarboxylic Acid Receptor 2 With the Ketone Body 3-Hydroxybutyrate and Niacin in Patients With Chronic Heart Failure: Hemodynamic and Metabolic Effects.
Gopalasingam N, Christensen KH, Berg Hansen K, Nielsen R, Johannsen M, Gormsen LC, Boedtkjer E, Nørregaard R, Møller N, Wiggers H. Gopalasingam N, et al. Among authors: johannsen m. J Am Heart Assoc. 2023 Jun 20;12(12):e029849. doi: 10.1161/JAHA.123.029849. Epub 2023 Jun 10. J Am Heart Assoc. 2023. PMID: 37301762 Free PMC article. Clinical Trial.
A Retrospective Metabolomics Analysis of Gamma-Hydroxybutyrate in Humans: New Potential Markers and Changes in Metabolism Related to GHB Consumption.
Wang T, Nielsen KL, Frisch K, Lassen JK, Nielsen CB, Andersen CU, Villesen P, Andreasen MF, Hasselstrøm JB, Johannsen M. Wang T, et al. Among authors: johannsen m. Front Pharmacol. 2022 Mar 3;13:816376. doi: 10.3389/fphar.2022.816376. eCollection 2022. Front Pharmacol. 2022. PMID: 35308203 Free PMC article.
191 results