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Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung.
Dörner PJ, Anandakumar H, Röwekamp I, Fiocca Vernengo F, Millet Pascual-Leone B, Krzanowski M, Sellmaier J, Brüning U, Fritsche-Guenther R, Pfannkuch L, Kurth F, Milek M, Igbokwe V, Löber U, Gutbier B, Holstein M, Heinz GA, Mashreghi MF, Schulte LN, Klatt AB, Caesar S, Wienhold SM, Offermanns S, Mack M, Witzenrath M, Jordan S, Beule D, Kirwan JA, Forslund SK, Wilck N, Bartolomaeus H, Heimesaat MM, Opitz B. Dörner PJ, et al. Among authors: heimesaat mm. Nat Commun. 2024 Mar 30;15(1):2788. doi: 10.1038/s41467-024-47149-z. Nat Commun. 2024. PMID: 38555356 Free PMC article.
The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia.
Witzenrath M, Pache F, Lorenz D, Koppe U, Gutbier B, Tabeling C, Reppe K, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat MM, Bereswill S, van der Linden M, Tschopp J, Mitchell TJ, Suttorp N, Opitz B. Witzenrath M, et al. Among authors: heimesaat mm. J Immunol. 2011 Jul 1;187(1):434-40. doi: 10.4049/jimmunol.1003143. Epub 2011 Jun 6. J Immunol. 2011. PMID: 21646297
Ly6C(high) monocytes control cerebral toxoplasmosis.
Biswas A, Bruder D, Wolf SA, Jeron A, Mack M, Heimesaat MM, Dunay IR. Biswas A, et al. Among authors: heimesaat mm. J Immunol. 2015 Apr 1;194(7):3223-35. doi: 10.4049/jimmunol.1402037. Epub 2015 Feb 20. J Immunol. 2015. PMID: 25710908
Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.
Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C, Opitz B. Robak OH, et al. Among authors: heimesaat mm. J Clin Invest. 2018 Aug 1;128(8):3535-3545. doi: 10.1172/JCI97065. Epub 2018 Jul 16. J Clin Invest. 2018. PMID: 29771684 Free PMC article.
IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota.
Röwekamp I, Maschirow L, Rabes A, Fiocca Vernengo F, Hamann L, Heinz GA, Mashreghi MF, Caesar S, Milek M, Fagundes Fonseca AC, Wienhold SM, Nouailles G, Yao L, Mousavi S, Bruder D, Boehme JD, Puzianowska-Kuznicka M, Beule D, Witzenrath M; CAPNETZ Study Group; Löhning M, Klose CSN, Heimesaat MM, Diefenbach A, Opitz B. Röwekamp I, et al. Among authors: heimesaat mm. Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2310864121. doi: 10.1073/pnas.2310864121. Epub 2024 May 23. Proc Natl Acad Sci U S A. 2024. PMID: 38781213
Role of Blimp-1 in programing Th effector cells into IL-10 producers.
Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi MF, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kühl AA, Heimesaat MM, Esser C, Im SH, Radbruch A, Rutz S, Scheffold A. Neumann C, et al. Among authors: heimesaat mm. J Exp Med. 2014 Aug 25;211(9):1807-19. doi: 10.1084/jem.20131548. Epub 2014 Jul 29. J Exp Med. 2014. PMID: 25073792 Free PMC article.
220 results