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Page 1
Tumor cell-based liquid biopsy using high-throughput microfluidic enrichment of entire leukapheresis product.
Mishra A, Huang SB, Dubash T, Burr R, Edd JF, Wittner BS, Cunneely QE, Putaturo VR, Deshpande A, Antmen E, Gopinathan KA, Otani K, Miyazawa Y, Kwak JE, Guay SY, Kelly J, Walsh J, Nieman L, Galler I, Chan P, Lawrence MS, Sullivan RJ, Bardia A, Micalizzi DS, Sequist LV, Lee RJ, Franses JW, Ting DT, Brunker PAR, Maheswaran S, Miyamoto DT, Haber DA, Toner M. Mishra A, et al. Among authors: wittner bs. bioRxiv [Preprint]. 2024 Mar 14:2024.03.13.583573. doi: 10.1101/2024.03.13.583573. bioRxiv. 2024. PMID: 38559183 Free PMC article. Preprint.
A microfluidic device for label-free, physical capture of circulating tumor cell clusters.
Sarioglu AF, Aceto N, Kojic N, Donaldson MC, Zeinali M, Hamza B, Engstrom A, Zhu H, Sundaresan TK, Miyamoto DT, Luo X, Bardia A, Wittner BS, Ramaswamy S, Shioda T, Ting DT, Stott SL, Kapur R, Maheswaran S, Haber DA, Toner M. Sarioglu AF, et al. Among authors: wittner bs. Nat Methods. 2015 Jul;12(7):685-91. doi: 10.1038/nmeth.3404. Epub 2015 May 18. Nat Methods. 2015. PMID: 25984697 Free PMC article.
Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis.
Aceto N, Bardia A, Miyamoto DT, Donaldson MC, Wittner BS, Spencer JA, Yu M, Pely A, Engstrom A, Zhu H, Brannigan BW, Kapur R, Stott SL, Shioda T, Ramaswamy S, Ting DT, Lin CP, Toner M, Haber DA, Maheswaran S. Aceto N, et al. Among authors: wittner bs. Cell. 2014 Aug 28;158(5):1110-1122. doi: 10.1016/j.cell.2014.07.013. Cell. 2014. PMID: 25171411 Free PMC article.
RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance.
Miyamoto DT, Zheng Y, Wittner BS, Lee RJ, Zhu H, Broderick KT, Desai R, Fox DB, Brannigan BW, Trautwein J, Arora KS, Desai N, Dahl DM, Sequist LV, Smith MR, Kapur R, Wu CL, Shioda T, Ramaswamy S, Ting DT, Toner M, Maheswaran S, Haber DA. Miyamoto DT, et al. Among authors: wittner bs. Science. 2015 Sep 18;349(6254):1351-6. doi: 10.1126/science.aab0917. Science. 2015. PMID: 26383955 Free PMC article.
Molecular signatures of circulating melanoma cells for monitoring early response to immune checkpoint therapy.
Hong X, Sullivan RJ, Kalinich M, Kwan TT, Giobbie-Hurder A, Pan S, LiCausi JA, Milner JD, Nieman LT, Wittner BS, Ho U, Chen T, Kapur R, Lawrence DP, Flaherty KT, Sequist LV, Ramaswamy S, Miyamoto DT, Lawrence M, Toner M, Isselbacher KJ, Maheswaran S, Haber DA. Hong X, et al. Among authors: wittner bs. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2467-2472. doi: 10.1073/pnas.1719264115. Epub 2018 Feb 16. Proc Natl Acad Sci U S A. 2018. PMID: 29453278 Free PMC article.
A Digital RNA Signature of Circulating Tumor Cells Predicting Early Therapeutic Response in Localized and Metastatic Breast Cancer.
Kwan TT, Bardia A, Spring LM, Giobbie-Hurder A, Kalinich M, Dubash T, Sundaresan T, Hong X, LiCausi JA, Ho U, Silva EJ, Wittner BS, Sequist LV, Kapur R, Miyamoto DT, Toner M, Haber DA, Maheswaran S. Kwan TT, et al. Among authors: wittner bs. Cancer Discov. 2018 Oct;8(10):1286-1299. doi: 10.1158/2159-8290.CD-18-0432. Epub 2018 Aug 13. Cancer Discov. 2018. PMID: 30104333 Free PMC article.
Differential Kinase Activity Across Prostate Tumor Compartments Defines Sensitivity to Target Inhibition.
Karabacak NM, Zheng Y, Dubash TD, Burr R, Micalizzi DS, Wittner BS, Lin M, Wiley DF, Comaills V, Emmons E, Niederhoffer KL, Ho U, Ukleja J, Che D, Stowe H, Nieman LT, Haas W, Stott SL, Lawrence MS, Ting DT, Miyamoto DT, Haber DA, Toner M, Maheswaran S. Karabacak NM, et al. Among authors: wittner bs. Cancer Res. 2022 Mar 15;82(6):1084-1097. doi: 10.1158/0008-5472.CAN-21-2609. Cancer Res. 2022. PMID: 35045985 Free PMC article.
Evaluation of endocrine resistance using ESR1 genotyping of circulating tumor cells and plasma DNA.
Sundaresan TK, Dubash TD, Zheng Z, Bardia A, Wittner BS, Aceto N, Silva EJ, Fox DB, Liebers M, Kapur R, Iafrate J, Toner M, Maheswaran S, Haber DA. Sundaresan TK, et al. Among authors: wittner bs. Breast Cancer Res Treat. 2021 Jul;188(1):43-52. doi: 10.1007/s10549-021-06270-z. Epub 2021 Jun 8. Breast Cancer Res Treat. 2021. PMID: 34101078 Free PMC article.
Androgen receptor signaling in circulating tumor cells as a marker of hormonally responsive prostate cancer.
Miyamoto DT, Lee RJ, Stott SL, Ting DT, Wittner BS, Ulman M, Smas ME, Lord JB, Brannigan BW, Trautwein J, Bander NH, Wu CL, Sequist LV, Smith MR, Ramaswamy S, Toner M, Maheswaran S, Haber DA. Miyamoto DT, et al. Among authors: wittner bs. Cancer Discov. 2012 Nov;2(11):995-1003. doi: 10.1158/2159-8290.CD-12-0222. Epub 2012 Oct 23. Cancer Discov. 2012. PMID: 23093251 Free PMC article.
Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition.
Yu M, Bardia A, Wittner BS, Stott SL, Smas ME, Ting DT, Isakoff SJ, Ciciliano JC, Wells MN, Shah AM, Concannon KF, Donaldson MC, Sequist LV, Brachtel E, Sgroi D, Baselga J, Ramaswamy S, Toner M, Haber DA, Maheswaran S. Yu M, et al. Among authors: wittner bs. Science. 2013 Feb 1;339(6119):580-4. doi: 10.1126/science.1228522. Science. 2013. PMID: 23372014 Free PMC article.
48 results