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An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis.
Yenilmez B, Wetoska N, Kelly M, Echeverria D, Min K, Lifshitz L, Alterman JF, Hassler MR, Hildebrand S, DiMarzio C, McHugh N, Vangjeli L, Sousa J, Pan M, Han X, Brehm MA, Khvorova A, Czech MP. Yenilmez B, et al. Among authors: czech mp. Mol Ther. 2022 Mar 2;30(3):1329-1342. doi: 10.1016/j.ymthe.2021.11.007. Epub 2021 Nov 11. Mol Ther. 2022. PMID: 34774753 Free PMC article.
Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice.
Yenilmez B, Kelly M, Zhang GF, Wetoska N, Ilkayeva OR, Min K, Rowland L, DiMarzio C, He W, Raymond N, Lifshitz L, Pan M, Han X, Xie J, Friedline RH, Kim JK, Gao G, Herman MA, Newgard CB, Czech MP. Yenilmez B, et al. Among authors: czech mp. J Biol Chem. 2022 Oct;298(10):102401. doi: 10.1016/j.jbc.2022.102401. Epub 2022 Aug 18. J Biol Chem. 2022. PMID: 35988648 Free PMC article.
CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease.
Tsagkaraki E, Nicoloro SM, DeSouza T, Solivan-Rivera J, Desai A, Lifshitz LM, Shen Y, Kelly M, Guilherme A, Henriques F, Amrani N, Ibraheim R, Rodriguez TC, Luk K, Maitland S, Friedline RH, Tauer L, Hu X, Kim JK, Wolfe SA, Sontheimer EJ, Corvera S, Czech MP. Tsagkaraki E, et al. Among authors: czech mp. Nat Commun. 2021 Nov 26;12(1):6931. doi: 10.1038/s41467-021-27190-y. Nat Commun. 2021. PMID: 34836963 Free PMC article.
De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics.
Rowland LA, Guilherme A, Henriques F, DiMarzio C, Munroe S, Wetoska N, Kelly M, Reddig K, Hendricks G, Pan M, Han X, Ilkayeva OR, Newgard CB, Czech MP. Rowland LA, et al. Among authors: czech mp. Nat Commun. 2023 Mar 13;14(1):1362. doi: 10.1038/s41467-023-37016-8. Nat Commun. 2023. PMID: 36914626 Free PMC article.
The adipocyte supersystem of insulin and cAMP signaling.
Guilherme A, Rowland LA, Wang H, Czech MP. Guilherme A, et al. Among authors: czech mp. Trends Cell Biol. 2023 Apr;33(4):340-354. doi: 10.1016/j.tcb.2022.07.009. Epub 2022 Aug 18. Trends Cell Biol. 2023. PMID: 35989245 Free PMC article. Review.
335 results