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De novo variants in GABRA4 are associated with a neurological phenotype including developmental delay, behavioral abnormalities and epilepsy.
Eur J Hum Genet. 2024 Apr 2. doi: 10.1038/s41431-024-01600-3. Online ahead of print.
Eur J Hum Genet. 2024.
PMID: 38565639
Free energy profile of the substrate-induced occlusion of the human serotonin transporter.
Alves da Silva L, Lazzarin E, Gradisch R, Clarke A, Stockner T.
Alves da Silva L, et al. Among authors: gradisch r.
J Neurochem. 2024 Feb 5. doi: 10.1111/jnc.16061. Online ahead of print.
J Neurochem. 2024.
PMID: 38316690
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Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors.
Gradisch R, Schlögl K, Lazzarin E, Niello M, Maier J, Mayer FP, Alves da Silva L, Skopec SMC, Blakely RD, Sitte HH, Mihovilovic MD, Stockner T.
Gradisch R, et al.
Nat Commun. 2024 Jan 10;15(1):417. doi: 10.1038/s41467-023-44637-6.
Nat Commun. 2024.
PMID: 38195746
Free PMC article.
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Persistent binding at dopamine transporters determines sustained psychostimulant effects.
Niello M, Sideromenos S, Gradisch R, O Shea R, Schwazer J, Maier J, Kastner N, Sandtner W, Jäntsch K, Lupica CR, Hoffman AF, Lubec G, Loland CJ, Stockner T, Pollak DD, Baumann MH, Sitte HH.
Niello M, et al. Among authors: gradisch r.
Proc Natl Acad Sci U S A. 2023 Feb 7;120(6):e2114204120. doi: 10.1073/pnas.2114204120. Epub 2023 Feb 2.
Proc Natl Acad Sci U S A. 2023.
PMID: 36730201
Free PMC article.
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Structural basis of organic cation transporter-3 inhibition.
Khanppnavar B, Maier J, Herborg F, Gradisch R, Lazzarin E, Luethi D, Yang JW, Qi C, Holy M, Jäntsch K, Kudlacek O, Schicker K, Werge T, Gether U, Stockner T, Korkhov VM, Sitte HH.
Khanppnavar B, et al. Among authors: gradisch r.
Nat Commun. 2022 Nov 7;13(1):6714. doi: 10.1038/s41467-022-34284-8.
Nat Commun. 2022.
PMID: 36344565
Free PMC article.
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Occlusion of the human serotonin transporter is mediated by serotonin-induced conformational changes in the bundle domain.
Gradisch R, Szöllősi D, Niello M, Lazzarin E, Sitte HH, Stockner T.
Gradisch R, et al.
J Biol Chem. 2022 Mar;298(3):101613. doi: 10.1016/j.jbc.2022.101613. Epub 2022 Jan 21.
J Biol Chem. 2022.
PMID: 35065961
Free PMC article.
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The role of the degenerate nucleotide binding site in type I ABC exporters.
Stockner T, Gradisch R, Schmitt L.
Stockner T, et al. Among authors: gradisch r.
FEBS Lett. 2020 Dec;594(23):3815-3838. doi: 10.1002/1873-3468.13997. Epub 2020 Nov 27.
FEBS Lett. 2020.
PMID: 33179257
Free PMC article.
Review.
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Allosteric Modulation of Neurotransmitter Transporters as a Therapeutic Strategy.
Niello M, Gradisch R, Loland CJ, Stockner T, Sitte HH.
Niello M, et al. Among authors: gradisch r.
Trends Pharmacol Sci. 2020 Jul;41(7):446-463. doi: 10.1016/j.tips.2020.04.006. Epub 2020 May 26.
Trends Pharmacol Sci. 2020.
PMID: 32471654
Free PMC article.
Review.
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