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A multi-ancestry GWAS of Fuchs corneal dystrophy highlights the contributions of laminins, collagen, and endothelial cell regulation.
Gorman BR, Francis M, Nealon CL, Halladay CW, Duro N, Markianos K, Genovese G, Hysi PG, Choquet H, Afshari NA, Li YJ; VA Million Veteran Program; Gaziano JM, Hung AM, Wu WC, Greenberg PB, Pyarajan S, Lass JH, Peachey NS, Iyengar SK. Gorman BR, et al. Among authors: iyengar sk. Commun Biol. 2024 Apr 6;7(1):418. doi: 10.1038/s42003-024-06046-3. Commun Biol. 2024. PMID: 38582945 Free PMC article.
Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy.
Afshari NA, Igo RP Jr, Morris NJ, Stambolian D, Sharma S, Pulagam VL, Dunn S, Stamler JF, Truitt BJ, Rimmler J, Kuot A, Croasdale CR, Qin X, Burdon KP, Riazuddin SA, Mills R, Klebe S, Minear MA, Zhao J, Balajonda E, Rosenwasser GO, Baratz KH, Mootha VV, Patel SV, Gregory SG, Bailey-Wilson JE, Price MO, Price FW Jr, Craig JE, Fingert JH, Gottsch JD, Aldave AJ, Klintworth GK, Lass JH, Li YJ, Iyengar SK. Afshari NA, et al. Among authors: iyengar sk. Nat Commun. 2017 Mar 30;8:14898. doi: 10.1038/ncomms14898. Nat Commun. 2017. PMID: 28358029 Free PMC article.
Differing roles for TCF4 and COL8A2 in central corneal thickness and fuchs endothelial corneal dystrophy.
Igo RP Jr, Kopplin LJ, Joseph P, Truitt B, Fondran J, Bardenstein D, Aldave AJ, Croasdale CR, Price MO, Rosenwasser M, Lass JH, Iyengar SK; FECD Genetics Multi-center Study Group. Igo RP Jr, et al. Among authors: iyengar sk. PLoS One. 2012;7(10):e46742. doi: 10.1371/journal.pone.0046742. Epub 2012 Oct 23. PLoS One. 2012. PMID: 23110055 Free PMC article.
A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus.
Hardcastle AJ, Liskova P, Bykhovskaya Y, McComish BJ, Davidson AE, Inglehearn CF, Li X, Choquet H, Habeeb M, Lucas SEM, Sahebjada S, Pontikos N, Lopez KER, Khawaja AP, Ali M, Dudakova L, Skalicka P, Van Dooren BTH, Geerards AJM, Haudum CW, Faro VL, Tenen A, Simcoe MJ, Patasova K, Yarrand D, Yin J, Siddiqui S, Rice A, Farraj LA, Chen YI, Rahi JS, Krauss RM, Theusch E, Charlesworth JC, Szczotka-Flynn L, Toomes C, Meester-Smoor MA, Richardson AJ, Mitchell PA, Taylor KD, Melles RB, Aldave AJ, Mills RA, Cao K, Chan E, Daniell MD, Wang JJ, Rotter JI, Hewitt AW, MacGregor S, Klaver CCW, Ramdas WD, Craig JE, Iyengar SK, O'Brart D, Jorgenson E, Baird PN, Rabinowitz YS, Burdon KP, Hammond CJ, Tuft SJ, Hysi PG. Hardcastle AJ, et al. Among authors: iyengar sk. Commun Biol. 2021 Mar 1;4(1):266. doi: 10.1038/s42003-021-01784-0. Commun Biol. 2021. PMID: 33649486 Free PMC article.
A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program.
Verma A, Tsao NL, Thomann LO, Ho YL, Iyengar SK, Luoh SW, Carr R, Crawford DC, Efird JT, Huffman JE, Hung A, Ivey KL, Levin MG, Lynch J, Natarajan P, Pyarajan S, Bick AG, Costa L, Genovese G, Hauger R, Madduri R, Pathak GA, Polimanti R, Voight B, Vujkovic M, Zekavat SM, Zhao H, Ritchie MD; VA Million Veteran Program COVID-19 Science Initiative; Chang KM, Cho K, Casas JP, Tsao PS, Gaziano JM, O'Donnell C, Damrauer SM, Liao KP. Verma A, et al. Among authors: iyengar sk. PLoS Genet. 2022 Apr 28;18(4):e1010113. doi: 10.1371/journal.pgen.1010113. eCollection 2022 Apr. PLoS Genet. 2022. PMID: 35482673 Free PMC article.
Glaucoma Genetic Risk Scores in the Million Veteran Program.
Waksmunski AR, Kinzy TG, Cruz LA, Nealon CL, Halladay CW, Simpson P, Canania RL, Anthony SA, Roncone DP, Sawicki Rogers L, Leber JN, Dougherty JM, Greenberg PB, Sullivan JM, Wu WC, Iyengar SK, Crawford DC, Peachey NS, Cooke Bailey JN; VA Million Veteran Program. Waksmunski AR, et al. Among authors: iyengar sk. Ophthalmology. 2022 Nov;129(11):1263-1274. doi: 10.1016/j.ophtha.2022.06.012. Epub 2022 Jun 17. Ophthalmology. 2022. PMID: 35718050 Free PMC article.
A multicenter study to map genes for Fuchs endothelial corneal dystrophy: baseline characteristics and heritability.
Louttit MD, Kopplin LJ, Igo RP Jr, Fondran JR, Tagliaferri A, Bardenstein D, Aldave AJ, Croasdale CR, Price MO, Rosenwasser GO, Lass JH, Iyengar SK; FECD Genetics Multi-Center Study Group. Louttit MD, et al. Among authors: iyengar sk. Cornea. 2012 Jan;31(1):26-35. doi: 10.1097/ICO.0b013e31821c9b8f. Cornea. 2012. PMID: 22045388 Free PMC article.
Relationship of Fuchs endothelial corneal dystrophy severity to central corneal thickness.
Kopplin LJ, Przepyszny K, Schmotzer B, Rudo K, Babineau DC, Patel SV, Verdier DD, Jurkunas U, Iyengar SK, Lass JH; Fuchs' Endothelial Corneal Dystrophy Genetics Multi-Center Study Group. Kopplin LJ, et al. Among authors: iyengar sk. Arch Ophthalmol. 2012 Apr;130(4):433-9. doi: 10.1001/archophthalmol.2011.1626. Arch Ophthalmol. 2012. PMID: 22491913 Free PMC article.
197 results