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ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity.
Feng W, Ladewig E, Salsabeel N, Zhao H, Lee YS, Gopalan A, Lange M, Luo H, Kang W, Fan N, Rosiek E, de Stanchina E, Chen Y, Carver BS, Leslie CS, Sawyers CL. Feng W, et al. Among authors: chen y. bioRxiv [Preprint]. 2024 Apr 6:2023.05.15.540839. doi: 10.1101/2023.05.15.540839. bioRxiv. 2024. PMID: 38585869 Free PMC article. Preprint.
Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling.
Chan JM, Zaidi S, Love JR, Zhao JL, Setty M, Wadosky KM, Gopalan A, Choo ZN, Persad S, Choi J, LaClair J, Lawrence KE, Chaudhary O, Xu T, Masilionis I, Linkov I, Wang S, Lee C, Barlas A, Morris MJ, Mazutis L, Chaligne R, Chen Y, Goodrich DW, Karthaus WR, Pe'er D, Sawyers CL. Chan JM, et al. Among authors: chen y. Science. 2022 Sep 9;377(6611):1180-1191. doi: 10.1126/science.abn0478. Epub 2022 Aug 18. Science. 2022. PMID: 35981096 Free PMC article.
NSD2 maintains lineage plasticity and castration-resistance in neuroendocrine prostate cancer.
Li JJ, Vasciaveo A, Karagiannis D, Sun Z, Chen X, Socciarelli F, Frankenstein Z, Zou M, Pannellini T, Chen Y, Gardner K, Robinson BD, de Bono J, Abate-Shen C, Rubin MA, Loda M, Sawyers CL, Califano A, Lu C, Shen MM. Li JJ, et al. Among authors: chen x, chen y. bioRxiv [Preprint]. 2023 Jul 19:2023.07.18.549585. doi: 10.1101/2023.07.18.549585. bioRxiv. 2023. PMID: 37502956 Free PMC article. Preprint.
BET inhibitors as a therapeutic intervention in gastrointestinal gene signature-positive castration-resistant prostate cancer.
Shukla S, Li D, Nguyen H, Conner J, Bayshtok G, Cho WH, Pachai M, Teri N, Campeau E, Attwell S, Trojer P, Ostrovnaya I, Gopalan A, Corey E, Chi P, Chen Y. Shukla S, et al. Among authors: chen y. bioRxiv [Preprint]. 2024 Mar 13:2024.03.09.584256. doi: 10.1101/2024.03.09.584256. bioRxiv. 2024. PMID: 38559135 Free PMC article. Preprint.
ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis.
Bose R, Karthaus WR, Armenia J, Abida W, Iaquinta PJ, Zhang Z, Wongvipat J, Wasmuth EV, Shah N, Sullivan PS, Doran MG, Wang P, Patruno A, Zhao Y; International SU2C/PCF Prostate Cancer Dream Team; Zheng D, Schultz N, Sawyers CL. Bose R, et al. Nature. 2017 Jun 29;546(7660):671-675. doi: 10.1038/nature22820. Epub 2017 Jun 14. Nature. 2017. PMID: 28614298 Free PMC article.
CD38 in Advanced Prostate Cancers.
Guo C, Crespo M, Gurel B, Dolling D, Rekowski J, Sharp A, Petremolo A, Sumanasuriya S, Rodrigues DN, Ferreira A, Pereira R, Figueiredo I, Mehra N, Lambros MBK, Neeb A, Gil V, Seed G, Terstappen L, Alimonti A, Drake CG, Yuan W, de Bono JS; International SU2C PCF Prostate Cancer Dream Team. Guo C, et al. Eur Urol. 2021 Jun;79(6):736-746. doi: 10.1016/j.eururo.2021.01.017. Epub 2021 Mar 5. Eur Urol. 2021. PMID: 33678520 Free PMC article.
Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets.
Tang F, Xu D, Wang S, Wong CK, Martinez-Fundichely A, Lee CJ, Cohen S, Park J, Hill CE, Eng K, Bareja R, Han T, Liu EM, Palladino A, Di W, Gao D, Abida W, Beg S, Puca L, Meneses M, de Stanchina E, Berger MF, Gopalan A, Dow LE, Mosquera JM, Beltran H, Sternberg CN, Chi P, Scher HI, Sboner A, Chen Y, Khurana E. Tang F, et al. Among authors: chen y. Science. 2022 May 27;376(6596):eabe1505. doi: 10.1126/science.abe1505. Epub 2022 May 27. Science. 2022. PMID: 35617398 Free PMC article.
ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer.
Li D, Zhan Y, Wang N, Tang F, Lee CJ, Bayshtok G, Moore AR, Wong EWP, Pachai MR, Xie Y, Sher J, Zhao JL, Khudoynazarova M, Gopalan A, Chan J, Khurana E, Shepherd P, Navone NM, Chi P, Chen Y. Li D, et al. Among authors: chen y. Sci Adv. 2023 Apr 5;9(14):eadc9446. doi: 10.1126/sciadv.adc9446. Epub 2023 Apr 5. Sci Adv. 2023. PMID: 37018402 Free PMC article.
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